EC number:1.14.13.n7
| ID: | 1.14.13.n7 |
|---|---|
| Description: | 4-nitrophenol 2-hydroxylase. |
| Alternative Name: |
CYP2E1. |
| Cath: | 1.10.630.10; |
3D structure
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| RHEA:26205 | 4-nitrophenol + H(+) + NADPH + O2 = 4-nitrocatechol + H2O + NADP(+) |
| RULE(radius=1) | [*:1]-[N;H0;+0:2]1-[CH;+0:3]=[C;H0;+0:4](-[*:5])-[CH2;+0:6]-[CH;+0:7]=[CH;+0:8]-1.[*:9]:[cH;+0:10]:[*:11].[H+;H0:12].[O;H0;+0:13]=[O;H0;+0:14]>>[*:1]-[n+;H0:2]1:[cH;+0:3]:[c;H0;+0:4](-[*:5]):[cH;+0:6]:[cH;+0:7]:[cH;+0:8]:1.[*:9]:[c;H0;+0:10](:[*:11])-[OH;+0:13].[OH2;+0:14] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Both cytochromes P450 2E1 and 3A are involved in the O-hydroxylation of p-nitrophenol, a catalytic activity known to be specific for P450 2E1. | Zerilli A, Ratanasavanh D, Lucas D, Goasduff T, Dréano Y, Menard C, Picart D, Berthou F | 1997 Oct | 9348445 |