EC number:1.14.14.1
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen |
| 1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor |
| ID: | 1.14.14.1 | ||
|---|---|---|---|
| Description: | Unspecific monooxygenase. | ||
| Alternative Name: |
Xenobiotic monooxygenase. Microsomal P450. Microsomal monooxygenase. Flavoprotein-linked monooxygenase. Cytochrome P450. Aryl-4-monooxygenase. Aryl hydrocarbon hydroxylase. | ||
| Prosite: | PDOC00081; | ||
| PDB: |
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| Cath: | 1.10.630.10; 3.40.50.80; 1.20.990.10; 2.40.30.10; 3.40.50.360; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.14.14.1 |
| BRENDA Enzyme Link: | BRENDA 1.14.14.1 |
| KEGG Enzyme Link: | KEGG1.14.14.1 |
| BioCyc Enzyme Link: | BioCyc 1.14.14.1 |
| ExPASy Enzyme Link: | ExPASy1.14.14.1 |
| EC2PDB Enzyme Link: | EC2PDB 1.14.14.1 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.14.14.1 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.14.14.1 |
| IntEnz Enzyme Link: | IntEnz 1.14.14.1 |
| MEDLINE Enzyme Link: | MEDLINE 1.14.14.1 |
EC number:1.14.14.1
| MSA: | |
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| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:17149 | an alkane + O2 + reduced [NADPH--hemoprotein reductase] = a primary alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] |
| RULE(radius=1) | [*:1]-[CH3;+0:2].[*:3]-[N;H0;+0:4]1-[*:5]:[*:6]-[NH;+0:7]-[c;H0;+0:8](:[*:9]):[c;H0;+0:10]-1:[nH;+0:11]:[*:12].[O;H0;+0:13]=[O;H0;+0:14]>>[*:1]-[CH2;+0:2]-[OH;+0:13].[*:3]-[n;H0;+0:4]1:[*:5]:[*:6]:[n;H0;+0:7]:[c;H0;+0:8](:[*:9])-[c;H0;+0:10]:1:[n;H0;+0:11]:[*:12].[OH2;+0:14] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Differences in soluble P-450 hemoproteins from livers of rats treated with phenobarbital and 3-methylcholanthrene. | Fujita T, Mannering GJ | 1971 Aug | 5132997 |
| Characterization of three forms of rabbit microsomal cytochrome P-450 by peptide mapping utilizing limited proteolysis in sodium dodecyl sulfate and analysis by gel electrophoresis. | Johnson EF, Zounes MC, Muller-Eberhard U | 1979 Jan | 434823 |
| Aminopyrine metabolism by multiple forms of cytochrome P-450 from rat liver microsomes: simultaneous quantitation of four aminopyrine metabolites by high-performance liquid chromatography. | Imaoka S, Inoue K, Funae Y | 1988 Aug 15 | 3415241 |
| Properties of electrophoretically homogeneous phenobarbital-inducible and beta-naphthoflavone-inducible forms of liver microsomal cytochrome P-450. | Haugen DA, Coon MJ | 1976 Dec 25 | 187601 |
| The biochemistry of aromatic amines. III. Enzymic hydroxylation by rat-liver microsomes. | BOOTH J, BOYLAND E | 1957 May | 13426111 |