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1. Oxidoreductases

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor

ID:

1.14.14.102

Description:

N-methylcoclaurine 3'-monooxygenase.

Alternative Name:

N-methylcoclaurine 3'-hydroxylase.
CYP80B1.
(S)-N-methylcoclaurine 3'-hydroxylase.

Prosite:

PDOC00081;

PDB:

PDB	Scop

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UniProtKB Enzyme Link:	UniProtKB 1.14.14.102
BRENDA Enzyme Link:	BRENDA 1.14.14.102
KEGG Enzyme Link:	KEGG1.14.14.102
BioCyc Enzyme Link:	BioCyc 1.14.14.102
ExPASy Enzyme Link:	ExPASy1.14.14.102
EC2PDB Enzyme Link:	EC2PDB 1.14.14.102
ExplorEnz Enzyme Link:	ExplorEnz 1.14.14.102
PRIAM enzyme-specific profiles Link:	PRIAM 1.14.14.102
IntEnz Enzyme Link:	IntEnz 1.14.14.102
MEDLINE Enzyme Link:	MEDLINE 1.14.14.102

RHEA:16649	(S)-N-methylcoclaurine + O2 + reduced [NADPH--hemoprotein reductase] = (S)-3'-hydroxy-N-methylcoclaurine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RULE(radius=1)	[:1]-[N;H0;+0:2]1-[CH;+0:3]=[C;H0;+0:4](-[:5])-[CH2;+0:6]-[CH;+0:7]=[CH;+0:8]-1.[:9]:[cH;+0:10]:[:11].[H+;H0:12].[O;H0;+0:13]=[O;H0;+0:14]>>[:1]-[n+;H0:2]1:[cH;+0:3]:[c;H0;+0:4](-[:5]):[cH;+0:6]:[cH;+0:7]:[cH;+0:8]:1.[:9]:[c;H0;+0:10](:[:11])-[OH;+0:13].[OH2;+0:14]
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Title	Authors	Date	PubMed ID
Molecular cloning and functional heterologous expression of two alleles encoding (S)-N-methylcoclaurine 3'-hydroxylase (CYP80B1), a new methyl jasmonate-inducible cytochrome P-450-dependent mono-oxygenase of benzylisoquinoline alkaloid biosynthesis.	Pauli HH, Kutchan TM	1998 Mar	9681018