EC number:1.14.14.103
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen |
| 1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor |
| ID: | 1.14.14.103 | ||
|---|---|---|---|
| Description: | Tabersonine 16-hydroxylase. | ||
| Alternative Name: |
Tabersonine-11-hydroxylase. CYP71D12. | ||
| Prosite: | PDOC00081; | ||
| PDB: |
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3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.14.14.103 |
| BRENDA Enzyme Link: | BRENDA 1.14.14.103 |
| KEGG Enzyme Link: | KEGG1.14.14.103 |
| BioCyc Enzyme Link: | BioCyc 1.14.14.103 |
| ExPASy Enzyme Link: | ExPASy1.14.14.103 |
| EC2PDB Enzyme Link: | EC2PDB 1.14.14.103 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.14.14.103 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.14.14.103 |
| IntEnz Enzyme Link: | IntEnz 1.14.14.103 |
| MEDLINE Enzyme Link: | MEDLINE 1.14.14.103 |
EC number:1.14.14.103
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:14133 | O2 + reduced [NADPH--hemoprotein reductase] + tabersonine = 16-hydroxytabersonine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] |
| RULE(radius=1) | [*:1]-[N;H0;+0:2]1-[CH;+0:3]=[C;H0;+0:4](-[*:5])-[CH2;+0:6]-[CH;+0:7]=[CH;+0:8]-1.[*:9]:[cH;+0:10]:[*:11].[H+;H0:12].[O;H0;+0:13]=[O;H0;+0:14]>>[*:1]-[n+;H0:2]1:[cH;+0:3]:[c;H0;+0:4](-[*:5]):[cH;+0:6]:[cH;+0:7]:[cH;+0:8]:1.[*:9]:[c;H0;+0:10](:[*:11])-[OH;+0:13].[OH2;+0:14] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| A pair of tabersonine 16-hydroxylases initiates the synthesis of vindoline in an organ-dependent manner in Catharanthus roseus. | Besseau S, Kellner F, Lanoue A, Thamm AM, Salim V, Schneider B, Geu-Flores F, Höfer R, Guirimand G, Guihur A, Oudin A, Glevarec G, Foureau E, Papon N, Clastre M, Giglioli-Guivarc'h N, St-Pierre B, Werck-Reichhart D, Burlat V, De Luca V, O'Connor SE, Courdavault V | 2013 Dec | 24108213 |
| A Cytochrome P-450 Monooxygenase Catalyzes the First Step in the Conversion of Tabersonine to Vindoline in Catharanthus roseus. | St-Pierre B, De Luca V | 1995 Sep | 12228585 |