EC number:1.14.14.105

Enzyme

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     1. Oxidoreductases
        1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
            1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
ID:1.14.14.105
Description:Taxane 10-beta-hydroxylase.
Alternative Name: CYP725A1.
5-alpha-taxadienol-10-beta-hydroxylase.
Prosite: PDOC00081;
PDB:
PDBScop

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 1.14.14.105
BRENDA Enzyme Link: BRENDA 1.14.14.105
KEGG Enzyme Link: KEGG1.14.14.105
BioCyc Enzyme Link: BioCyc 1.14.14.105
ExPASy Enzyme Link: ExPASy1.14.14.105
EC2PDB Enzyme Link: EC2PDB 1.14.14.105
ExplorEnz Enzyme Link: ExplorEnz 1.14.14.105
PRIAM enzyme-specific profiles Link: PRIAM 1.14.14.105
IntEnz Enzyme Link: IntEnz 1.14.14.105
MEDLINE Enzyme Link: MEDLINE 1.14.14.105

EC number:1.14.14.105

MSA:

1.14.14.105;
Phylogenetic Tree:

1.14.14.105;
Uniprot:
M-CSA:
RHEA:15241 O2 + reduced [NADPH--hemoprotein reductase] + taxa-4(20),11-dien-5alpha-yl acetate = 10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RULE(radius=1) [*:1]-[CH2;+0:2]-[*:3].[*:4]-[N;H0;+0:5]1-[CH;+0:6]=[C;H0;+0:7](-[*:8])-[CH2;+0:9]-[CH;+0:10]=[CH;+0:11]-1.[H+;H0:12].[O;H0;+0:13]=[O;H0;+0:14]>>[*:1]-[CH;+0:2](-[*:3])-[OH;+0:13].[*:4]-[n+;H0:5]1:[cH;+0:6]:[c;H0;+0:7](-[*:8]):[cH;+0:9]:[cH;+0:10]:[cH;+0:11]:1.[OH2;+0:14]
Reaction
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References

TitleAuthorsDatePubMed ID
Taxol biosynthesis: taxane 13 alpha-hydroxylase is a cytochrome P450-dependent monooxygenase.Jennewein S, Rithner CD, Williams RM, Croteau RB2001 Nov 2011707604
Taxol biosynthesis: differential transformations of taxadien-5 alpha-ol and its acetate ester by cytochrome P450 hydroxylases from Taxus suspension cells.Wheeler AL, Long RM, Ketchum RE, Rithner CD, Williams RM, Croteau R2001 Jun 1511396929
Molecular cloning of a cytochrome P450 taxane 10 beta-hydroxylase cDNA from Taxus and functional expression in yeast.Schoendorf A, Rithner CD, Williams RM, Croteau RB2001 Feb 1311171980