EC number:1.14.14.106

Enzyme

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     1. Oxidoreductases
        1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
            1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
ID:1.14.14.106
Description:Taxane 13-alpha-hydroxylase.
Alternative Name: CYP725A2.
Prosite: PDOC00081;
PDB:
PDBScop

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 1.14.14.106
BRENDA Enzyme Link: BRENDA 1.14.14.106
KEGG Enzyme Link: KEGG1.14.14.106
BioCyc Enzyme Link: BioCyc 1.14.14.106
ExPASy Enzyme Link: ExPASy1.14.14.106
EC2PDB Enzyme Link: EC2PDB 1.14.14.106
ExplorEnz Enzyme Link: ExplorEnz 1.14.14.106
PRIAM enzyme-specific profiles Link: PRIAM 1.14.14.106
IntEnz Enzyme Link: IntEnz 1.14.14.106
MEDLINE Enzyme Link: MEDLINE 1.14.14.106

EC number:1.14.14.106

MSA:

1.14.14.106;
Phylogenetic Tree:

1.14.14.106;
Uniprot:
M-CSA:
RHEA:18949 O2 + reduced [NADPH--hemoprotein reductase] + taxa-4(20),11-dien-5alpha-ol = H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + taxa-4(20),11-dien-5alpha,13alpha-diol
RULE(radius=1) [*:1]-[CH2;+0:2]-[*:3].[*:4]-[N;H0;+0:5]1-[CH;+0:6]=[C;H0;+0:7](-[*:8])-[CH2;+0:9]-[CH;+0:10]=[CH;+0:11]-1.[H+;H0:12].[O;H0;+0:13]=[O;H0;+0:14]>>[*:1]-[CH;+0:2](-[*:3])-[OH;+0:13].[*:4]-[n+;H0:5]1:[cH;+0:6]:[c;H0;+0:7](-[*:8]):[cH;+0:9]:[cH;+0:10]:[cH;+0:11]:1.[OH2;+0:14]
Reaction
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References

TitleAuthorsDatePubMed ID
Taxol biosynthesis: taxane 13 alpha-hydroxylase is a cytochrome P450-dependent monooxygenase.Jennewein S, Rithner CD, Williams RM, Croteau RB2001 Nov 2011707604
Taxol biosynthesis: differential transformations of taxadien-5 alpha-ol and its acetate ester by cytochrome P450 hydroxylases from Taxus suspension cells.Wheeler AL, Long RM, Ketchum RE, Rithner CD, Williams RM, Croteau R2001 Jun 1511396929