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1. Oxidoreductases

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor

ID:

1.14.14.107

Description:

Ent-kaurenoic acid monooxygenase.

Alternative Name:

Ent-kaurenoic acid oxidase.
CYP88A3.

Prosite:

PDOC00081;

PDB:

PDB	Scop

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UniProtKB Enzyme Link:	UniProtKB 1.14.14.107
BRENDA Enzyme Link:	BRENDA 1.14.14.107
KEGG Enzyme Link:	KEGG1.14.14.107
BioCyc Enzyme Link:	BioCyc 1.14.14.107
ExPASy Enzyme Link:	ExPASy1.14.14.107
EC2PDB Enzyme Link:	EC2PDB 1.14.14.107
ExplorEnz Enzyme Link:	ExplorEnz 1.14.14.107
PRIAM enzyme-specific profiles Link:	PRIAM 1.14.14.107
IntEnz Enzyme Link:	IntEnz 1.14.14.107
MEDLINE Enzyme Link:	MEDLINE 1.14.14.107

RHEA:33219	ent-kaur-16-en-19-oate + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = gibberellin A12 + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]
RULE(radius=1)	[:1]-[N;H0;+0:2]1-[CH;+0:3]=[C;H0;+0:4](-[:5])-[CH2;+0:6]-[CH;+0:7]=[CH;+0:8]-1.[:9]=[C;H0;+0:10](-[OH;+0:11])-[:12]-[:13]-[CH2;+0:14]-[CH2;+0:15]-[C;H0;+0:16](-[:17])(-[:18])-[:19].[H+;H0:20].[H+;H0:21].[O;H0;+0:22]=[O;H0;+0:23].[O;H0;+0:24]=[O;H0;+0:25]>>[:1]-[n+;H0:2]1:[cH;+0:3]:[c;H0;+0:4](-[:5]):[cH;+0:6]:[cH;+0:7]:[cH;+0:8]:1.[:9]=[C;H0;+0:10](-[OH;+0:25])-[:12]-[:13]-[CH;+0:14](-[C;H0;+0:15](=[O;H0;+0:23])-[OH;+0:24])-[C;H0;+0:16](-[:17])(-[:18])-[:19].[OH2;+0:22].[OH2;+0:11]
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Title	Authors	Date	PubMed ID
The CYP88A cytochrome P450, ent-kaurenoic acid oxidase, catalyzes three steps of the gibberellin biosynthesis pathway.	Helliwell CA, Chandler PM, Poole A, Dennis ES, Peacock WJ	2001 Feb 13	11172076