EnzyMine

Download

EC Tree

1. Oxidoreductases

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor

ID:	1.14.14.114
Description:	Amorpha-4,11-diene 12 monooxygenase.
Alternative Name:	CYP71AV1.

Click one PDB to see exact 3D structure provided by NGL.

Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.

PDB	Click once to unfold,double click to fold.

UniProtKB Enzyme Link:	UniProtKB 1.14.14.114
BRENDA Enzyme Link:	BRENDA 1.14.14.114
KEGG Enzyme Link:	KEGG1.14.14.114
BioCyc Enzyme Link:	BioCyc 1.14.14.114
ExPASy Enzyme Link:	ExPASy1.14.14.114
EC2PDB Enzyme Link:	EC2PDB 1.14.14.114
ExplorEnz Enzyme Link:	ExplorEnz 1.14.14.114
PRIAM enzyme-specific profiles Link:	PRIAM 1.14.14.114
IntEnz Enzyme Link:	IntEnz 1.14.14.114
MEDLINE Enzyme Link:	MEDLINE 1.14.14.114

RHEA:32999	(+)-amorpha-4,11-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = (+)-artemisinate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]
RULE(radius=1)	[:1]-[CH3;+0:2].[:3]-[N;H0;+0:4]1-[CH;+0:5]=[C;H0;+0:6](-[:7])-[CH2;+0:8]-[CH;+0:9]=[CH;+0:10]-1.[O;H0;+0:11]=[O;H0;+0:12]>>[:1]-[C;H0;+0:2](=[O;H0;+0:11])-[OH;+0:12].[:3]-[n+;H0:4]1:[cH;+0:5]:[c;H0;+0:6](-[:7]):[cH;+0:8]:[cH;+0:9]:[cH;+0:10]:1
Reaction
Core-to-Core	More

Title	Authors	Date	PubMed ID
Production of the antimalarial drug precursor artemisinic acid in engineered yeast.	Ro DK, Paradise EM, Ouellet M, Fisher KJ, Newman KL, Ndungu JM, Ho KA, Eachus RA, Ham TS, Kirby J, Chang MC, Withers ST, Shiba Y, Sarpong R, Keasling JD	2006 Apr 13	16612385
Artemisia annua L. (Asteraceae) trichome-specific cDNAs reveal CYP71AV1, a cytochrome P450 with a key role in the biosynthesis of the antimalarial sesquiterpene lactone artemisinin.	Teoh KH, Polichuk DR, Reed DW, Nowak G, Covello PS	2006 Feb 20	16458889