EC number:1.14.14.116
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen |
| 1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor |
| ID: | 1.14.14.116 |
|---|---|
| Description: | Averantin hydroxylase. |
| Alternative Name: |
CYP60A1. AVN hydroxylase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.14.14.116 |
| BRENDA Enzyme Link: | BRENDA 1.14.14.116 |
| KEGG Enzyme Link: | KEGG1.14.14.116 |
| BioCyc Enzyme Link: | BioCyc 1.14.14.116 |
| ExPASy Enzyme Link: | ExPASy1.14.14.116 |
| EC2PDB Enzyme Link: | EC2PDB 1.14.14.116 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.14.14.116 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.14.14.116 |
| IntEnz Enzyme Link: | IntEnz 1.14.14.116 |
| MEDLINE Enzyme Link: | MEDLINE 1.14.14.116 |
EC number:1.14.14.116
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:35575 | (1'S)-averantin + O2 + reduced [NADPH--hemoprotein reductase] = (1'S,5'R)-5'-hydroxyaverantin + H2O + oxidized [NADPH--hemoprotein reductase] |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[*:3].[*:4]-[N;H0;+0:5]1-[CH;+0:6]=[C;H0;+0:7](-[*:8])-[CH2;+0:9]-[CH;+0:10]=[CH;+0:11]-1.[H+;H0:12].[H+;H0:13].[O;H0;+0:14]=[O;H0;+0:15]>>[*:1]-[CH;+0:2](-[*:3])-[OH;+0:14].[*:4]-[n+;H0:5]1:[cH;+0:6]:[c;H0;+0:7](-[*:8]):[cH;+0:9]:[cH;+0:10]:[cH;+0:11]:1.[OH2;+0:15] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| avnA, a gene encoding a cytochrome P-450 monooxygenase, is involved in the conversion of averantin to averufin in aflatoxin biosynthesis in Aspergillus parasiticus. | Yu J, Chang PK, Cary JW, Bhatnagar D, Cleveland TE | 1997 Apr | 9097431 |
| Stereochemistry during aflatoxin biosynthesis: conversion of norsolorinic acid to averufin. | Yabe K, Matsuyama Y, Ando Y, Nakajima H, Hamasaki T | 1993 Aug | 8368836 |
| RHEA:35571 | (1'S)-averantin + O2 + reduced [NADPH--hemoprotein reductase] = (1'S,5'S)-5'-hydroxyaverantin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[*:3].[*:4]-[N;H0;+0:5]1-[CH;+0:6]=[C;H0;+0:7](-[*:8])-[CH2;+0:9]-[CH;+0:10]=[CH;+0:11]-1.[H+;H0:12].[O;H0;+0:13]=[O;H0;+0:14]>>[*:1]-[CH;+0:2](-[*:3])-[OH;+0:13].[*:4]-[n+;H0:5]1:[cH;+0:6]:[c;H0;+0:7](-[*:8]):[cH;+0:9]:[cH;+0:10]:[cH;+0:11]:1.[OH2;+0:14] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| avnA, a gene encoding a cytochrome P-450 monooxygenase, is involved in the conversion of averantin to averufin in aflatoxin biosynthesis in Aspergillus parasiticus. | Yu J, Chang PK, Cary JW, Bhatnagar D, Cleveland TE | 1997 Apr | 9097431 |
| Stereochemistry during aflatoxin biosynthesis: conversion of norsolorinic acid to averufin. | Yabe K, Matsuyama Y, Ando Y, Nakajima H, Hamasaki T | 1993 Aug | 8368836 |