EC number:1.14.14.117
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen |
| 1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor |
| ID: | 1.14.14.117 |
|---|---|
| Description: | Aflatoxin B synthase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.14.14.117 |
| BRENDA Enzyme Link: | BRENDA 1.14.14.117 |
| KEGG Enzyme Link: | KEGG1.14.14.117 |
| BioCyc Enzyme Link: | BioCyc 1.14.14.117 |
| ExPASy Enzyme Link: | ExPASy1.14.14.117 |
| EC2PDB Enzyme Link: | EC2PDB 1.14.14.117 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.14.14.117 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.14.14.117 |
| IntEnz Enzyme Link: | IntEnz 1.14.14.117 |
| MEDLINE Enzyme Link: | MEDLINE 1.14.14.117 |
EC number:1.14.14.117
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:35763 | 8-O-methyldihydrosterigmatocystin + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = aflatoxin B2 + CO2 + 2 H(+) + H2O + methanol + 2 oxidized [NADPH--hemoprotein reductase] |
| RULE(radius=1) | [*:1]-[C;H0;+0:2]1=[CH;+0:3]-[N;H0;+0:4](-[*:5])-[CH;+0:6]=[CH;+0:7]-[CH2;+0:8]-1.([*:9]-[N;H0;+0:10]1-[CH;+0:11]=[C;H0;+0:12](-[*:13])-[CH2;+0:14]-[CH;+0:15]=[CH;+0:16]-1.[*:17]-[P;H0;+0:18](=[*:19])(-[*:20])-[OH;+0:21]).[*:22]:[c;H0;+0:23]1:[cH;+0:24]:[cH;+0:25]:[cH;+0:26]:[c;H0;+0:27](-[O;H0;+0:28]-[CH3;+0:29]):[*:30]:1:[c;H0;+0:31](:[*:32])=[O;H0;+0:33].[H+;H0:34].[H+;H0:35].[O;H0;+0:36]=[O;H0;+0:37].[O;H0;+0:38]=[O;H0;+0:39]>>([*:17]-[P;H0;+0:18](=[*:19])(-[*:20])-[OH;+0:36].[*:9]-[n+;H0:10]1:[cH;+0:11]:[c;H0;+0:12](-[*:13]):[cH;+0:14]:[cH;+0:15]:[cH;+0:16]:1).[*:1]-[c;H0;+0:2]1:[cH;+0:3]:[n+;H0:4](-[*:5]):[cH;+0:6]:[cH;+0:7]:[cH;+0:8]:1.[*:22]:[c;H0;+0:23](=[O;H0;+0:33]):[*:30]1:[c;H0;+0:31](:[*:32])-[CH2;+0:25]-[CH2;+0:26]-[C;H0;+0:27]-1=[O;H0;+0:28].[CH3;+0:29]-[OH;+0:37].[O;H0;+0:38]=[C;H0;+0:24]=[O;H0;+0:39].[OH2;+0:21] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Characterization of the critical amino acids of an Aspergillus parasiticus cytochrome P-450 monooxygenase encoded by ordA that is involved in the biosynthesis of aflatoxins B1, G1, B2, and G2. | Yu J, Chang PK, Ehrlich KC, Cary JW, Montalbano B, Dyer JM, Bhatnagar D, Cleveland TE | 1998 Dec | 9835571 |
| Enzymological evidence for separate pathways for aflatoxin B1 and B2 biosynthesis. | Bhatnagar D, Cleveland TE, Kingston DG | 1991 Apr 30 | 1902378 |
| RHEA:35759 | 8-O-methylsterigmatocystin + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = aflatoxin B1 + CO2 + 2 H(+) + H2O + methanol + 2 oxidized [NADPH--hemoprotein reductase] |
| RULE(radius=1) | [*:1]-[C;H0;+0:2]1=[CH;+0:3]-[N;H0;+0:4](-[*:5])-[CH;+0:6]=[CH;+0:7]-[CH2;+0:8]-1.([*:9]-[N;H0;+0:10]1-[CH;+0:11]=[C;H0;+0:12](-[*:13])-[CH2;+0:14]-[CH;+0:15]=[CH;+0:16]-1.[*:17]-[P;H0;+0:18](=[*:19])(-[*:20])-[OH;+0:21]).[*:22]:[c;H0;+0:23]1:[cH;+0:24]:[cH;+0:25]:[cH;+0:26]:[c;H0;+0:27](-[O;H0;+0:28]-[CH3;+0:29]):[*:30]:1:[c;H0;+0:31](:[*:32])=[O;H0;+0:33].[H+;H0:34].[H+;H0:35].[O;H0;+0:36]=[O;H0;+0:37].[O;H0;+0:38]=[O;H0;+0:39]>>([*:17]-[P;H0;+0:18](=[*:19])(-[*:20])-[OH;+0:36].[*:9]-[n+;H0:10]1:[cH;+0:11]:[c;H0;+0:12](-[*:13]):[cH;+0:14]:[cH;+0:15]:[cH;+0:16]:1).[*:1]-[c;H0;+0:2]1:[cH;+0:3]:[n+;H0:4](-[*:5]):[cH;+0:6]:[cH;+0:7]:[cH;+0:8]:1.[*:22]:[c;H0;+0:23](=[O;H0;+0:33]):[*:30]1:[c;H0;+0:31](:[*:32])-[CH2;+0:25]-[CH2;+0:26]-[C;H0;+0:27]-1=[O;H0;+0:28].[CH3;+0:29]-[OH;+0:37].[O;H0;+0:38]=[C;H0;+0:24]=[O;H0;+0:39].[OH2;+0:21] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Characterization of the critical amino acids of an Aspergillus parasiticus cytochrome P-450 monooxygenase encoded by ordA that is involved in the biosynthesis of aflatoxins B1, G1, B2, and G2. | Yu J, Chang PK, Ehrlich KC, Cary JW, Montalbano B, Dyer JM, Bhatnagar D, Cleveland TE | 1998 Dec | 9835571 |
| Enzymological evidence for separate pathways for aflatoxin B1 and B2 biosynthesis. | Bhatnagar D, Cleveland TE, Kingston DG | 1991 Apr 30 | 1902378 |