EC Tree |
1. Oxidoreductases |
1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen |
1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor |
ID: | 1.14.14.12 |
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Description: | 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione monooxygenase. |
Cath: | 1.10.540.10; 1.20.140.10; 2.40.110.10; |
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Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.UniProtKB Enzyme Link: | UniProtKB 1.14.14.12 |
BRENDA Enzyme Link: | BRENDA 1.14.14.12 |
KEGG Enzyme Link: | KEGG1.14.14.12 |
BioCyc Enzyme Link: | BioCyc 1.14.14.12 |
ExPASy Enzyme Link: | ExPASy1.14.14.12 |
EC2PDB Enzyme Link: | EC2PDB 1.14.14.12 |
ExplorEnz Enzyme Link: | ExplorEnz 1.14.14.12 |
PRIAM enzyme-specific profiles Link: | PRIAM 1.14.14.12 |
IntEnz Enzyme Link: | IntEnz 1.14.14.12 |
MEDLINE Enzyme Link: | MEDLINE 1.14.14.12 |
MSA: | |
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Phylogenetic Tree: | |
Uniprot: | |
M-CSA: |
RHEA:31731 | 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMNH2 + O2 = 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMN + H(+) + H2O |
RULE(radius=1) | [*:1]-[N;H0;+0:2]1-[*:3]:[*:4]-[NH;+0:5]-[c;H0;+0:6](:[*:7]):[c;H0;+0:8]-1:[nH;+0:9]:[*:10].[*:11]:[cH;+0:12]:[*:13].[O;H0;+0:14]=[O;H0;+0:15]>>[*:1]-[n;H0;+0:2]1:[*:3]:[*:4]:[n;H0;+0:5]:[c;H0;+0:6](:[*:7])-[c;H0;+0:8]:1:[n;H0;+0:9]:[*:10].[*:11]:[c;H0;+0:12](:[*:13])-[OH;+0:14].[OH2;+0:15] |
Reaction | ![]() |
Core-to-Core |
Title | Authors | Date | PubMed ID |
---|---|---|---|
A flavin-dependent monooxygenase from Mycobacterium tuberculosis involved in cholesterol catabolism. | Dresen C, Lin LY, D'Angelo I, Tocheva EI, Strynadka N, Eltis LD | 2010 Jul 16 | 20448045 |