Enzyme

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EC Tree
     1. Oxidoreductases
        1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
            1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
ID:1.14.14.12
Description:3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione monooxygenase.
Cath: 1.10.540.10; 1.20.140.10; 2.40.110.10;

3D structure

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References

External Links

UniProtKB Enzyme Link: UniProtKB 1.14.14.12
BRENDA Enzyme Link: BRENDA 1.14.14.12
KEGG Enzyme Link: KEGG1.14.14.12
BioCyc Enzyme Link: BioCyc 1.14.14.12
ExPASy Enzyme Link: ExPASy1.14.14.12
EC2PDB Enzyme Link: EC2PDB 1.14.14.12
ExplorEnz Enzyme Link: ExplorEnz 1.14.14.12
PRIAM enzyme-specific profiles Link: PRIAM 1.14.14.12
IntEnz Enzyme Link: IntEnz 1.14.14.12
MEDLINE Enzyme Link: MEDLINE 1.14.14.12
MSA:

1.14.14.12;

Phylogenetic Tree:

1.14.14.12;

Uniprot:
M-CSA:
RHEA:31731 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMNH2 + O2 = 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMN + H(+) + H2O
RULE(radius=1) [*:1]-[N;H0;+0:2]1-[*:3]:[*:4]-[NH;+0:5]-[c;H0;+0:6](:[*:7]):[c;H0;+0:8]-1:[nH;+0:9]:[*:10].[*:11]:[cH;+0:12]:[*:13].[O;H0;+0:14]=[O;H0;+0:15]>>[*:1]-[n;H0;+0:2]1:[*:3]:[*:4]:[n;H0;+0:5]:[c;H0;+0:6](:[*:7])-[c;H0;+0:8]:1:[n;H0;+0:9]:[*:10].[*:11]:[c;H0;+0:12](:[*:13])-[OH;+0:14].[OH2;+0:15]
Reaction
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References

TitleAuthorsDatePubMed ID
A flavin-dependent monooxygenase from Mycobacterium tuberculosis involved in cholesterol catabolism.Dresen C, Lin LY, D'Angelo I, Tocheva EI, Strynadka N, Eltis LD2010 Jul 1620448045