EnzyMine

Download

EC Tree

1. Oxidoreductases

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor

ID:	1.14.14.120
Description:	Dammarenediol 12-hydroxylase.
Alternative Name:	Protopanaxadiol synthase. CYP716A47.

Click one PDB to see exact 3D structure provided by NGL.

Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.

PDB	Click once to unfold,double click to fold.

UniProtKB Enzyme Link:	UniProtKB 1.14.14.120
BRENDA Enzyme Link:	BRENDA 1.14.14.120
KEGG Enzyme Link:	KEGG1.14.14.120
BioCyc Enzyme Link:	BioCyc 1.14.14.120
ExPASy Enzyme Link:	ExPASy1.14.14.120
EC2PDB Enzyme Link:	EC2PDB 1.14.14.120
ExplorEnz Enzyme Link:	ExplorEnz 1.14.14.120
PRIAM enzyme-specific profiles Link:	PRIAM 1.14.14.120
IntEnz Enzyme Link:	IntEnz 1.14.14.120
MEDLINE Enzyme Link:	MEDLINE 1.14.14.120

RHEA:38579	dammarenediol-II + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + protopanaxadiol
RULE(radius=1)	[:1]-[CH2;+0:2]-[:3].[:4]-[N;H0;+0:5]1-[CH;+0:6]=[C;H0;+0:7](-[:8])-[CH2;+0:9]-[CH;+0:10]=[CH;+0:11]-1.[H+;H0:12].[O;H0;+0:13]=[O;H0;+0:14]>>[:1]-[CH;+0:2](-[:3])-[OH;+0:13].[:4]-[n+;H0:5]1:[cH;+0:6]:[c;H0;+0:7](-[:8]):[cH;+0:9]:[cH;+0:10]:[cH;+0:11]:1.[OH2;+0:14]
Reaction
Core-to-Core	More

Title	Authors	Date	PubMed ID
The Cyt P450 enzyme CYP716A47 catalyzes the formation of protopanaxadiol from dammarenediol-II during ginsenoside biosynthesis in Panax ginseng.	Han JY, Kim HJ, Kwon YS, Choi YE	2011 Dec	22039120