EC number:1.14.14.121

Enzyme

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     1. Oxidoreductases
        1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
            1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
ID:1.14.14.121
Description:Protopanaxadiol 6-hydroxylase.
Alternative Name: Protopanaxatriol synthase.
CYP716A53v2.

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 1.14.14.121
BRENDA Enzyme Link: BRENDA 1.14.14.121
KEGG Enzyme Link: KEGG1.14.14.121
BioCyc Enzyme Link: BioCyc 1.14.14.121
ExPASy Enzyme Link: ExPASy1.14.14.121
EC2PDB Enzyme Link: EC2PDB 1.14.14.121
ExplorEnz Enzyme Link: ExplorEnz 1.14.14.121
PRIAM enzyme-specific profiles Link: PRIAM 1.14.14.121
IntEnz Enzyme Link: IntEnz 1.14.14.121
MEDLINE Enzyme Link: MEDLINE 1.14.14.121

EC number:1.14.14.121

MSA:

1.14.14.121;
Phylogenetic Tree:

1.14.14.121;
Uniprot:
M-CSA:
RHEA:22272 O2 + protopanaxadiol + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + protopanaxatriol
RULE(radius=1) [*:1]-[CH2;+0:2]-[*:3].[*:4]-[N;H0;+0:5]1-[CH;+0:6]=[C;H0;+0:7](-[*:8])-[CH2;+0:9]-[CH;+0:10]=[CH;+0:11]-1.[H+;H0:12].[O;H0;+0:13]=[O;H0;+0:14]>>[*:1]-[CH;+0:2](-[*:3])-[OH;+0:13].[*:4]-[n+;H0:5]1:[cH;+0:6]:[c;H0;+0:7](-[*:8]):[cH;+0:9]:[cH;+0:10]:[cH;+0:11]:1.[OH2;+0:14]
Reaction
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References

TitleAuthorsDatePubMed ID
Cytochrome P450 CYP716A53v2 catalyzes the formation of protopanaxatriol from protopanaxadiol during ginsenoside biosynthesis in Panax ginseng.Han JY, Hwang HS, Choi SW, Kim HJ, Choi YE2012 Sep22875608
Protopanaxadiol 6-hydroxylase and its role in regulating the ginsenoside heterogeneity in Panax notoginseng cells.Yue CJ, Zhou X, Zhong JJ2008 Aug 118351680