EC number:1.14.14.124
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen |
| 1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor |
| ID: | 1.14.14.124 |
|---|---|
| Description: | Dihydromonacolin L hydroxylase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.14.14.124 |
| BRENDA Enzyme Link: | BRENDA 1.14.14.124 |
| KEGG Enzyme Link: | KEGG1.14.14.124 |
| BioCyc Enzyme Link: | BioCyc 1.14.14.124 |
| ExPASy Enzyme Link: | ExPASy1.14.14.124 |
| EC2PDB Enzyme Link: | EC2PDB 1.14.14.124 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.14.14.124 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.14.14.124 |
| IntEnz Enzyme Link: | IntEnz 1.14.14.124 |
| MEDLINE Enzyme Link: | MEDLINE 1.14.14.124 |
EC number:1.14.14.124
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:42368 | dihydromonacolin L carboxylate + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + 2 H2O + monacolin L carboxylate + oxidized [NADPH--hemoprotein reductase] |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[CH2;+0:4]-[*:5].[*:6]-[N;H0;+0:7]1-[CH;+0:8]=[C;H0;+0:9](-[*:10])-[CH2;+0:11]-[CH;+0:12]=[CH;+0:13]-1.[H+;H0:14].[O;H0;+0:15]=[O;H0;+0:16]>>[*:1]-[C;H0;+0:2](-[*:3])=[CH;+0:4]-[*:5].[*:6]-[n+;H0:7]1:[cH;+0:8]:[c;H0;+0:9](-[*:10]):[cH;+0:11]:[cH;+0:12]:[cH;+0:13]:1.[OH2;+0:15].[OH2;+0:16] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Origin of monacolin L from Aspergillus terreus cultures. | Treiber LR, Reamer RA, Rooney CS, Ramjit HG | 1989 Jan | 2921224 |
| Isolation and biosynthesis of 3 alpha-hydroxy-3,5-dihydromonacolin L. | Nakamura T, Komagata D, Murakawa S, Sakai K, Endo A | 1990 Dec | 2276977 |
| Double oxidation of the cyclic nonaketide dihydromonacolin L to monacolin J by a single cytochrome P450 monooxygenase, LovA. | Barriuso J, Nguyen DT, Li JW, Roberts JN, MacNevin G, Chaytor JL, Marcus SL, Vederas JC, Ro DK | 2011 Jun 1 | 21495633 |