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1. Oxidoreductases

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor

ID:	1.14.14.125
Description:	Monacolin L hydroxylase.

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UniProtKB Enzyme Link:	UniProtKB 1.14.14.125
BRENDA Enzyme Link:	BRENDA 1.14.14.125
KEGG Enzyme Link:	KEGG1.14.14.125
BioCyc Enzyme Link:	BioCyc 1.14.14.125
ExPASy Enzyme Link:	ExPASy1.14.14.125
EC2PDB Enzyme Link:	EC2PDB 1.14.14.125
ExplorEnz Enzyme Link:	ExplorEnz 1.14.14.125
PRIAM enzyme-specific profiles Link:	PRIAM 1.14.14.125
IntEnz Enzyme Link:	IntEnz 1.14.14.125
MEDLINE Enzyme Link:	MEDLINE 1.14.14.125

RHEA:29599	monacolin L carboxylate + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + monacolin J carboxylate + oxidized [NADPH--hemoprotein reductase]
RULE(radius=1)	[:1]-[CH2;+0:2]-[:3].[:4]-[N;H0;+0:5]1-[CH;+0:6]=[C;H0;+0:7](-[:8])-[CH2;+0:9]-[CH;+0:10]=[CH;+0:11]-1.[H+;H0:12].[O;H0;+0:13]=[O;H0;+0:14]>>[:1]-[CH;+0:2](-[:3])-[OH;+0:13].[:4]-[n+;H0:5]1:[cH;+0:6]:[c;H0;+0:7](-[:8]):[cH;+0:9]:[cH;+0:10]:[cH;+0:11]:1.[OH2;+0:14]
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Title	Authors	Date	PubMed ID
Double oxidation of the cyclic nonaketide dihydromonacolin L to monacolin J by a single cytochrome P450 monooxygenase, LovA.	Barriuso J, Nguyen DT, Li JW, Roberts JN, MacNevin G, Chaytor JL, Marcus SL, Vederas JC, Ro DK	2011 Jun 1	21495633