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1. Oxidoreductases

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor

ID:	1.14.14.132
Description:	(-)-4'-demethyl-deoxypodophyllotoxin 4-hydroxylase.
Alternative Name:	CYP82D61.

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UniProtKB Enzyme Link:	UniProtKB 1.14.14.132
BRENDA Enzyme Link:	BRENDA 1.14.14.132
KEGG Enzyme Link:	KEGG1.14.14.132
BioCyc Enzyme Link:	BioCyc 1.14.14.132
ExPASy Enzyme Link:	ExPASy1.14.14.132
EC2PDB Enzyme Link:	EC2PDB 1.14.14.132
ExplorEnz Enzyme Link:	ExplorEnz 1.14.14.132
PRIAM enzyme-specific profiles Link:	PRIAM 1.14.14.132
IntEnz Enzyme Link:	IntEnz 1.14.14.132
MEDLINE Enzyme Link:	MEDLINE 1.14.14.132

RHEA:49032	(-)-4'-desmethyl-deoxypodophyllotoxin + O2 + reduced [NADPH--hemoprotein reductase] = 4'-demethylepipodophyllotoxin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RULE(radius=1)	[:1]-[CH2;+0:2]-[:3].[:4]-[N;H0;+0:5]1-[:6]:[:7]-[NH;+0:8]-[c;H0;+0:9](:[:10]):[c;H0;+0:11]-1:[nH;+0:12]:[:13].[O;H0;+0:14]=[O;H0;+0:15]>>[:1]-[CH;+0:2](-[:3])-[OH;+0:14].[:4]-[n;H0;+0:5]1:[:6]:[:7]:[n;H0;+0:8]:[c;H0;+0:9](:[:10])-[c;H0;+0:11]:1:[n;H0;+0:12]:[:13].[OH2;+0:15]
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Title	Authors	Date	PubMed ID
Six enzymes from mayapple that complete the biosynthetic pathway to the etoposide aglycone.	Lau W, Sattely ES	2015 Sep 11	26359402