EC number:1.14.14.133

Enzyme

Download
EC Tree
     1. Oxidoreductases
        1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
            1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
ID:1.14.14.133
Description:1,8-cineole 2-endo-monooxygenase.
Alternative Name: P450(cin).
CYP176A1.
CYP176A.

3D structure

Click one PDB to see exact 3D structure provided by NGL.

Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.
PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 1.14.14.133
BRENDA Enzyme Link: BRENDA 1.14.14.133
KEGG Enzyme Link: KEGG1.14.14.133
BioCyc Enzyme Link: BioCyc 1.14.14.133
ExPASy Enzyme Link: ExPASy1.14.14.133
EC2PDB Enzyme Link: EC2PDB 1.14.14.133
ExplorEnz Enzyme Link: ExplorEnz 1.14.14.133
PRIAM enzyme-specific profiles Link: PRIAM 1.14.14.133
IntEnz Enzyme Link: IntEnz 1.14.14.133
MEDLINE Enzyme Link: MEDLINE 1.14.14.133

EC number:1.14.14.133

MSA:

1.14.14.133;
Phylogenetic Tree:

1.14.14.133;
Uniprot:
M-CSA:
RHEA:32899 1,8-cineole + O2 + reduced [flavodoxin] = 2-endo-hydroxy-1,8-cineole + H(+) + H2O + oxidized [flavodoxin]
RULE(radius=1) [*:1]-[CH2;+0:2]-[*:3].[*:4]-[N;H0;+0:5]1-[CH;+0:6]=[C;H0;+0:7](-[*:8])-[CH2;+0:9]-[CH;+0:10]=[CH;+0:11]-1.[H+;H0:12].[O;H0;+0:13]=[O;H0;+0:14]>>[*:1]-[CH;+0:2](-[*:3])-[OH;+0:13].[*:4]-[n+;H0:5]1:[cH;+0:6]:[c;H0;+0:7](-[*:8]):[cH;+0:9]:[cH;+0:10]:[cH;+0:11]:1.[OH2;+0:14]
Reaction
Core-to-Core More

References

TitleAuthorsDatePubMed ID
Oxidation of 1,8-cineole, the monoterpene cyclic ether originated from eucalyptus polybractea, by cytochrome P450 3A enzymes in rat and human liver microsomes.Miyazawa M, Shindo M, Shimada T2001 Feb11159812
Cytochrome P450(cin) (CYP176A), isolation, expression, and characterization.Hawkes DB, Adams GW, Burlingame AL, Ortiz de Montellano PR, De Voss JJ2002 Aug 212016226
Roles of cytochrome P450 3A enzymes in the 2-hydroxylation of 1,4-cineole, a monoterpene cyclic ether, by rat and human liver microsomes.Miyazawa M, Shindo M, Shimada T2001 Oct11695850