EC number:1.14.14.139
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen |
| 1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor |
| ID: | 1.14.14.139 | ||
|---|---|---|---|
| Description: | 5-beta-cholestane-3-alpha,7-alpha-diol 12-alpha-hydroxylase. | ||
| Alternative Name: |
Sterol 12-alpha-hydroxylase. CYP8B1. 5-beta-cholestane-3-alpha,7-alpha-diol 12-alpha-monooxygenase. | ||
| Prosite: | PDOC00081; | ||
| PDB: |
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3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.14.14.139 |
| BRENDA Enzyme Link: | BRENDA 1.14.14.139 |
| KEGG Enzyme Link: | KEGG1.14.14.139 |
| BioCyc Enzyme Link: | BioCyc 1.14.14.139 |
| ExPASy Enzyme Link: | ExPASy1.14.14.139 |
| EC2PDB Enzyme Link: | EC2PDB 1.14.14.139 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.14.14.139 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.14.14.139 |
| IntEnz Enzyme Link: | IntEnz 1.14.14.139 |
| MEDLINE Enzyme Link: | MEDLINE 1.14.14.139 |
EC number:1.14.14.139
| MSA: | |
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| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:15261 | 5beta-cholestane-3alpha,7alpha-diol + O2 + reduced [NADPH--hemoprotein reductase] = 5beta-cholestane-3alpha,7alpha,12alpha-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[*:3].[*:4]-[N;H0;+0:5]1-[CH;+0:6]=[C;H0;+0:7](-[*:8])-[CH2;+0:9]-[CH;+0:10]=[CH;+0:11]-1.[H+;H0:12].[O;H0;+0:13]=[O;H0;+0:14]>>[*:1]-[CH;+0:2](-[*:3])-[OH;+0:13].[*:4]-[n+;H0:5]1:[cH;+0:6]:[c;H0;+0:7](-[*:8]):[cH;+0:9]:[cH;+0:10]:[cH;+0:11]:1.[OH2;+0:14] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Gene structure of pig sterol 12alpha-hydroxylase (CYP8B1) and expression in fetal liver: comparison with expression of taurochenodeoxycholic acid 6alpha-hydroxylase (CYP4A21). | Lundell K, Wikvall K | 2003 Nov 15 | 14643796 |
| On the mechanism of bile acid inhibition of rat sterol 12alpha-hydroxylase gene (CYP8B1) transcription: roles of alpha-fetoprotein transcription factor and hepatocyte nuclear factor 4alpha. | Yang Y, Zhang M, Eggertsen G, Chiang JY | 2002 Jun 13 | 12069850 |
| Alpha 1-fetoprotein transcription factor is required for the expression of sterol 12alpha -hydroxylase, the specific enzyme for cholic acid synthesis. Potential role in the bile acid-mediated regulation of gene transcription. | del Castillo-Olivares A, Gil G | 2000 Jun 9 | 10747975 |
| The enzymes, regulation, and genetics of bile acid synthesis. | Russell DW | 2003 | 12543708 |