EC number:1.14.14.143

Enzyme

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     1. Oxidoreductases
        1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
            1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
ID:1.14.14.143
Description:(+)-menthofuran synthase.
Alternative Name: Menthofuran synthase.
(+)-pulegone 9-hydroxylase.
(+)-MFS.
Prosite: PDOC00081;
PDB:
PDBScop

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 1.14.14.143
BRENDA Enzyme Link: BRENDA 1.14.14.143
KEGG Enzyme Link: KEGG1.14.14.143
BioCyc Enzyme Link: BioCyc 1.14.14.143
ExPASy Enzyme Link: ExPASy1.14.14.143
EC2PDB Enzyme Link: EC2PDB 1.14.14.143
ExplorEnz Enzyme Link: ExplorEnz 1.14.14.143
PRIAM enzyme-specific profiles Link: PRIAM 1.14.14.143
IntEnz Enzyme Link: IntEnz 1.14.14.143
MEDLINE Enzyme Link: MEDLINE 1.14.14.143

EC number:1.14.14.143

MSA:

1.14.14.143;
Phylogenetic Tree:

1.14.14.143;
Uniprot:
M-CSA:
RHEA:25658 (R)-pulegone + O2 + reduced [NADPH--hemoprotein reductase] = (R)-menthofuran + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
RULE(radius=1) [*:1]-[C;H0;+0:2](-[CH3;+0:3])=[C;H0;+0:4](-[*:5])-[C;H0;+0:6](-[*:7])=[O;H0;+0:8].[*:9]-[N;H0;+0:10]1-[CH;+0:11]=[C;H0;+0:12](-[*:13])-[CH2;+0:14]-[CH;+0:15]=[CH;+0:16]-1.[H+;H0:17].[O;H0;+0:18]=[O;H0;+0:19]>>[*:1]-[c;H0;+0:2]1:[cH;+0:3]:[o;H0;+0:8]:[c;H0;+0:6](-[*:7]):[c;H0;+0:4]:1-[*:5].[*:9]-[n+;H0:10]1:[cH;+0:11]:[c;H0;+0:12](-[*:13]):[cH;+0:14]:[cH;+0:15]:[cH;+0:16]:1.[OH2;+0:18].[OH2;+0:19]
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References

TitleAuthorsDatePubMed ID
Menthofuran regulates essential oil biosynthesis in peppermint by controlling a downstream monoterpene reductase.Mahmoud SS, Croteau RB2003 Nov 2514623962
Demonstration that menthofuran synthase of mint (Mentha) is a cytochrome P450 monooxygenase: cloning, functional expression, and characterization of the responsible gene.Bertea CM, Schalk M, Karp F, Maffei M, Croteau R2001 Jun 1511396930