EC number:1.14.14.145
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen |
| 1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor |
| ID: | 1.14.14.145 | ||
|---|---|---|---|
| Description: | Abieta-7,13-dien-18-ol hydroxylase. | ||
| Alternative Name: |
CYP720B1. Abietadienol hydroxylase. | ||
| Prosite: | PDOC00081; | ||
| PDB: |
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3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.14.14.145 |
| BRENDA Enzyme Link: | BRENDA 1.14.14.145 |
| KEGG Enzyme Link: | KEGG1.14.14.145 |
| BioCyc Enzyme Link: | BioCyc 1.14.14.145 |
| ExPASy Enzyme Link: | ExPASy1.14.14.145 |
| EC2PDB Enzyme Link: | EC2PDB 1.14.14.145 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.14.14.145 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.14.14.145 |
| IntEnz Enzyme Link: | IntEnz 1.14.14.145 |
| MEDLINE Enzyme Link: | MEDLINE 1.14.14.145 |
EC number:1.14.14.145
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:26221 | abieta-7,13-dien-18-ol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = abieta-7,13-dien-18-oate + 3 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[OH;+0:3].[*:4]-[N;H0;+0:5]1-[CH;+0:6]=[C;H0;+0:7](-[*:8])-[CH2;+0:9]-[CH;+0:10]=[CH;+0:11]-1.[H+;H0:12].[O;H0;+0:13]=[O;H0;+0:14]>>[*:1]-[CH;+0:2]=[O;H0;+0:3].[*:4]-[n+;H0:5]1:[cH;+0:6]:[c;H0;+0:7](-[*:8]):[cH;+0:9]:[cH;+0:10]:[cH;+0:11]:1.[OH2;+0:13].[OH2;+0:14] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Diterpenoid resin acid biosynthesis in conifers: characterization of two cytochrome P450-dependent monooxygenases and an aldehyde dehydrogenase involved in abietic acid biosynthesis. | Funk C, Croteau R | 1994 Jan | 8311462 |
| Loblolly pine abietadienol/abietadienal oxidase PtAO (CYP720B1) is a multifunctional, multisubstrate cytochrome P450 monooxygenase. | Ro DK, Arimura G, Lau SY, Piers E, Bohlmann J | 2005 May 31 | 15911762 |
| Regulation of Oleoresinosis in Grand Fir (Abies grandis) (Coordinate Induction of Monoterpene and Diterpene Cyclases and Two Cytochrome P450-Dependent Diterpenoid Hydroxylases by Stem Wounding). | Funk C, Lewinsohn E, Vogel BS, Steele CL, Croteau R | 1994 Nov | 12232380 |