EC number:1.14.14.149
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen |
| 1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor |
| ID: | 1.14.14.149 | ||
|---|---|---|---|
| Description: | 5-epiaristolochene 1,3-dihydroxylase. | ||
| Alternative Name: |
EAH. CYP71D20. 5-epi-aristolochene 1,3-dihydroxylase. | ||
| Prosite: | PDOC00081; | ||
| PDB: |
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3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.14.14.149 |
| BRENDA Enzyme Link: | BRENDA 1.14.14.149 |
| KEGG Enzyme Link: | KEGG1.14.14.149 |
| BioCyc Enzyme Link: | BioCyc 1.14.14.149 |
| ExPASy Enzyme Link: | ExPASy1.14.14.149 |
| EC2PDB Enzyme Link: | EC2PDB 1.14.14.149 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.14.14.149 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.14.14.149 |
| IntEnz Enzyme Link: | IntEnz 1.14.14.149 |
| MEDLINE Enzyme Link: | MEDLINE 1.14.14.149 |
EC number:1.14.14.149
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:28226 | (+)-5-epi-aristolochene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = capsidiol + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase] |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[*:3]-[CH2;+0:4]-[*:5].[*:6]-[N;H0;+0:7]1-[CH;+0:8]=[C;H0;+0:9](-[*:10])-[CH2;+0:11]-[CH;+0:12]=[CH;+0:13]-1.[H+;H0:14].[H+;H0:15].[O;H0;+0:16]=[O;H0;+0:17].[O;H0;+0:18]=[O;H0;+0:19]>>[*:1]-[CH;+0:2](-[OH;+0:16])-[*:3]-[CH;+0:4](-[*:5])-[OH;+0:17].[*:6]-[n+;H0:7]1:[cH;+0:8]:[c;H0;+0:9](-[*:10]):[cH;+0:11]:[cH;+0:12]:[cH;+0:13]:1.[OH2;+0:18].[OH2;+0:19] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Functional characterization of premnaspirodiene oxygenase, a cytochrome P450 catalyzing regio- and stereo-specific hydroxylations of diverse sesquiterpene substrates. | Takahashi S, Yeo YS, Zhao Y, O'Maille PE, Greenhagen BT, Noel JP, Coates RM, Chappell J | 2007 Oct 26 | 17715131 |
| Kinetic and molecular analysis of 5-epiaristolochene 1,3-dihydroxylase, a cytochrome P450 enzyme catalyzing successive hydroxylations of sesquiterpenes. | Takahashi S, Zhao Y, O'Maille PE, Greenhagen BT, Noel JP, Coates RM, Chappell J | 2005 Feb 4 | 15522862 |
| Probing sesquiterpene hydroxylase activities in a coupled assay with terpene synthases. | Greenhagen BT, Griggs P, Takahashi S, Ralston L, Chappell J | 2003 Jan 15 | 12504906 |
| Cloning, heterologous expression, and functional characterization of 5-epi-aristolochene-1,3-dihydroxylase from tobacco (Nicotiana tabacum). | Ralston L, Kwon ST, Schoenbeck M, Ralston J, Schenk DJ, Coates RM, Chappell J | 2001 Sep 15 | 11556809 |