EC number:1.14.14.150
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen |
| 1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor |
| ID: | 1.14.14.150 |
|---|---|
| Description: | Costunolide synthase. |
| Alternative Name: |
CYP71BL2. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.14.14.150 |
| BRENDA Enzyme Link: | BRENDA 1.14.14.150 |
| KEGG Enzyme Link: | KEGG1.14.14.150 |
| BioCyc Enzyme Link: | BioCyc 1.14.14.150 |
| ExPASy Enzyme Link: | ExPASy1.14.14.150 |
| EC2PDB Enzyme Link: | EC2PDB 1.14.14.150 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.14.14.150 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.14.14.150 |
| IntEnz Enzyme Link: | IntEnz 1.14.14.150 |
| MEDLINE Enzyme Link: | MEDLINE 1.14.14.150 |
EC number:1.14.14.150
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:28230 | germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] = (+)-costunolide + 2 H2O + oxidized [NADPH--hemoprotein reductase] |
| RULE(radius=1) | ([*:1]-[CH2;+0:2]-[*:3].[*:4]-[OH;+0:5]).[*:6]-[N;H0;+0:7]1-[CH;+0:8]=[C;H0;+0:9](-[*:10])-[CH2;+0:11]-[CH;+0:12]=[CH;+0:13]-1.[H+;H0:14].[H+;H0:15].[O;H0;+0:16]=[O;H0;+0:17]>>[*:4]-[O;H0;+0:5]-[CH;+0:2](-[*:1])-[*:3].[*:6]-[n+;H0:7]1:[cH;+0:8]:[c;H0;+0:9](-[*:10]):[cH;+0:11]:[cH;+0:12]:[cH;+0:13]:1.[OH2;+0:16].[OH2;+0:17] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Reconstitution of the costunolide biosynthetic pathway in yeast and Nicotiana benthamiana. | Liu Q, Majdi M, Cankar K, Goedbloed M, Charnikhova T, Verstappen FW, de Vos RC, Beekwilder J, van der Krol S, Bouwmeester HJ | 2011 | 21858047 |
| Lettuce costunolide synthase (CYP71BL2) and its homolog (CYP71BL1) from sunflower catalyze distinct regio- and stereoselective hydroxylations in sesquiterpene lactone metabolism. | Ikezawa N, Göpfert JC, Nguyen DT, Kim SU, O'Maille PE, Spring O, Ro DK | 2011 Jun 17 | 21515683 |
| Biosynthesis of costunolide, dihydrocostunolide, and leucodin. Demonstration of cytochrome p450-catalyzed formation of the lactone ring present in sesquiterpene lactones of chicory. | de Kraker JW, Franssen MC, Joerink M, de Groot A, Bouwmeester HJ | 2002 May | 12011356 |