EC number:1.14.14.156
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen |
| 1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor |
| ID: | 1.14.14.156 |
|---|---|
| Description: | Tryptophan N-monooxygenase. |
| Alternative Name: |
Tryptophan N-hydroxylase. CYP79B3. CYP79B2. CYP79B1. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.14.14.156 |
| BRENDA Enzyme Link: | BRENDA 1.14.14.156 |
| KEGG Enzyme Link: | KEGG1.14.14.156 |
| BioCyc Enzyme Link: | BioCyc 1.14.14.156 |
| ExPASy Enzyme Link: | ExPASy1.14.14.156 |
| EC2PDB Enzyme Link: | EC2PDB 1.14.14.156 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.14.14.156 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.14.14.156 |
| IntEnz Enzyme Link: | IntEnz 1.14.14.156 |
| MEDLINE Enzyme Link: | MEDLINE 1.14.14.156 |
EC number:1.14.14.156
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:33279 | L-tryptophan + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = (E)-(indol-3-yl)acetaldehyde oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] |
| RULE(radius=1) | [*:1]-[C;H0;+0:2]1=[CH;+0:3]-[N;H0;+0:4](-[*:5])-[CH;+0:6]=[CH;+0:7]-[CH2;+0:8]-1.[*:9]-[CH;+0:10](-[NH2;+0:11])-[C;H0;+0:12](=[*:13])-[OH;+0:14].[*:15]-[N;H0;+0:16]1-[CH;+0:17]=[C;H0;+0:18](-[*:19])-[CH2;+0:20]-[CH;+0:21]=[CH;+0:22]-1.[H+;H0:23].[H+;H0:24].[O;H0;+0:25]=[O;H0;+0:26].[O;H0;+0:27]=[O;H0;+0:28]>>[*:9]-[CH;+0:10]=[N;H0;+0:11]-[OH;+0:25].[*:1]-[c;H0;+0:2]1:[cH;+0:3]:[n+;H0:4](-[*:5]):[cH;+0:6]:[cH;+0:7]:[cH;+0:8]:1.[*:15]-[n+;H0:16]1:[cH;+0:17]:[c;H0;+0:18](-[*:19]):[cH;+0:20]:[cH;+0:21]:[cH;+0:22]:1.[*:13]=[C;H0;+0:12]=[O;H0;+0:14].[OH2;+0:26].[OH2;+0:27].[OH2;+0:28] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| CYP79B1 from Sinapis alba converts tryptophan to indole-3-acetaldoxime. | Naur P, Hansen CH, Bak S, Hansen BG, Jensen NB, Nielsen HL, Halkier BA | 2003 Jan 1 | 12464264 |
| Cytochrome P450 CYP79B2 from Arabidopsis catalyzes the conversion of tryptophan to indole-3-acetaldoxime, a precursor of indole glucosinolates and indole-3-acetic acid. | Mikkelsen MD, Hansen CH, Wittstock U, Halkier BA | 2000 Oct 27 | 10922360 |