Enzyme

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     1. Oxidoreductases
        1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
            1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
ID:1.14.14.18
Description:Heme oxygenase (biliverdin-producing).
Alternative Name: Heme oxygenase (decyclizing).
Heme oxygenase.
Heme oxidase.
Prosite: PDOC00512;
PDB:
PDBScop
4WD4 8031679; 8044057; 8031679; 8044057; 8031679; 8044057; 8031679; 8044057;
1S8C 8031679; 8044057; 8031679; 8044057; 8031679; 8044057; 8031679; 8044057;
1NI6 8031679; 8044057; 8031679; 8044057; 8031679; 8044057; 8031679; 8044057;
6EHA 8031679; 8044057; 8031679; 8044057;
5BTQ 8031679; 8044057; 8031679; 8044057;
 » show all

Cath: 3.30.70.100; 3.30.70.3430; 1.20.910.10;

3D structure

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References

External Links

UniProtKB Enzyme Link: UniProtKB 1.14.14.18
BRENDA Enzyme Link: BRENDA 1.14.14.18
KEGG Enzyme Link: KEGG1.14.14.18
BioCyc Enzyme Link: BioCyc 1.14.14.18
ExPASy Enzyme Link: ExPASy1.14.14.18
EC2PDB Enzyme Link: EC2PDB 1.14.14.18
ExplorEnz Enzyme Link: ExplorEnz 1.14.14.18
PRIAM enzyme-specific profiles Link: PRIAM 1.14.14.18
IntEnz Enzyme Link: IntEnz 1.14.14.18
MEDLINE Enzyme Link: MEDLINE 1.14.14.18
MSA:

1.14.14.18;

Phylogenetic Tree:

1.14.14.18;

Uniprot:
M-CSA:
RHEA:21764 heme b + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = biliverdin IXalpha + CO + Fe(2+) + H(+) + 3 H2O + 3 oxidized [NADPH--hemoprotein reductase]
RULE(radius=1)
Reaction
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References

TitleAuthorsDatePubMed ID
Unusual diheme conformation of the heme-degrading protein from Mycobacterium tuberculosis.Chim N, Iniguez A, Nguyen TQ, Goulding CW2010 Jan 2219917297
Bacillus anthracis IsdG, a heme-degrading monooxygenase.Skaar EP, Gaspar AH, Schneewind O2006 Feb16428411
Comparison of the heme-free and -bound crystal structures of human heme oxygenase-1.Lad L, Schuller DJ, Shimizu H, Friedman J, Li H, Ortiz de Montellano PR, Poulos TL2003 Mar 712500973
Expression and biochemical properties of a ferredoxin-dependent heme oxygenase required for phytochrome chromophore synthesis.Muramoto T, Tsurui N, Terry MJ, Yokota A, Kohchi T2002 Dec12481078
The Arabidopsis photomorphogenic mutant hy1 is deficient in phytochrome chromophore biosynthesis as a result of a mutation in a plastid heme oxygenase.Muramoto T, Kohchi T, Yokota A, Hwang I, Goodman HM1999 Mar10072395