EC number:1.14.14.23
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen |
| 1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor |
| ID: | 1.14.14.23 | ||
|---|---|---|---|
| Description: | Cholesterol 7-alpha-monooxygenase. | ||
| Alternative Name: |
CYP7A1. Cholesterol 7-alpha-hydroxylase. | ||
| Prosite: | PDOC00081; | ||
| PDB: |
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| Cath: | 1.10.630.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.14.14.23 |
| BRENDA Enzyme Link: | BRENDA 1.14.14.23 |
| KEGG Enzyme Link: | KEGG1.14.14.23 |
| BioCyc Enzyme Link: | BioCyc 1.14.14.23 |
| ExPASy Enzyme Link: | ExPASy1.14.14.23 |
| EC2PDB Enzyme Link: | EC2PDB 1.14.14.23 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.14.14.23 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.14.14.23 |
| IntEnz Enzyme Link: | IntEnz 1.14.14.23 |
| MEDLINE Enzyme Link: | MEDLINE 1.14.14.23 |
EC number:1.14.14.23
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:21812 | cholesterol + O2 + reduced [NADPH--hemoprotein reductase] = 7alpha-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[*:3].[*:4]-[N;H0;+0:5]1-[*:6]:[*:7]-[NH;+0:8]-[c;H0;+0:9](:[*:10]):[c;H0;+0:11]-1:[nH;+0:12]:[*:13].[O;H0;+0:14]=[O;H0;+0:15]>>[*:1]-[CH;+0:2](-[*:3])-[OH;+0:14].[*:4]-[n;H0;+0:5]1:[*:6]:[*:7]:[n;H0;+0:8]:[c;H0;+0:9](:[*:10])-[c;H0;+0:11]:1:[n;H0;+0:12]:[*:13].[OH2;+0:15] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| 24-hydroxycholesterol is a substrate for hepatic cholesterol 7alpha-hydroxylase (CYP7A). | Norlin M, Toll A, Björkhem I, Wikvall K | 2000 Oct | 11013305 |
| Synchronous circadian rhythms of mRNA levels and activities of cholesterol 7 alpha-hydroxylase in the rabbit and rat. | Kai M, Eto T, Kondo K, Setoguchi Y, Higashi S, Maeda Y, Setoguchi T | 1995 Feb | 7751825 |
| Molecular cloning and sequence analysis of cDNA encoding human cholesterol 7 alpha-hydroxylase. | Noshiro M, Okuda K | 1990 Jul 30 | 2384150 |
| Cloning and regulation of cholesterol 7 alpha-hydroxylase, the rate-limiting enzyme in bile acid biosynthesis. | Jelinek DF, Andersson S, Slaughter CA, Russell DW | 1990 May 15 | 2335522 |
| Regulation of cholesterol 7 alpha-hydroxylase in the liver. Cloning, sequencing, and regulation of cholesterol 7 alpha-hydroxylase mRNA. | Li YC, Wang DP, Chiang JY | 1990 Jul 15 | 1694852 |
| PGC-1alpha activates CYP7A1 and bile acid biosynthesis. | Shin DJ, Campos JA, Gil G, Osborne TF | 2003 Dec 12 | 14522988 |