EC number:1.14.14.24
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen |
| 1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor |
| ID: | 1.14.14.24 |
|---|---|
| Description: | Vitamin D 25-hydroxylase. |
| Alternative Name: |
Vitamin D(3) 25-hydroxylase. Vitamin D(2) 25-hydroxylase. CYP2R1. |
| Cath: | 1.10.630.10; |
3D structure
Click one PDB to see exact 3D structure provided by NGL.
Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.References
External Links
| UniProtKB Enzyme Link: | UniProtKB 1.14.14.24 |
| BRENDA Enzyme Link: | BRENDA 1.14.14.24 |
| KEGG Enzyme Link: | KEGG1.14.14.24 |
| BioCyc Enzyme Link: | BioCyc 1.14.14.24 |
| ExPASy Enzyme Link: | ExPASy1.14.14.24 |
| EC2PDB Enzyme Link: | EC2PDB 1.14.14.24 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.14.14.24 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.14.14.24 |
| IntEnz Enzyme Link: | IntEnz 1.14.14.24 |
| MEDLINE Enzyme Link: | MEDLINE 1.14.14.24 |
EC number:1.14.14.24
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:32903 | calciol + O2 + reduced [NADPH--hemoprotein reductase] = calcidiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[*:4].[*:5]-[N;H0;+0:6]1-[CH;+0:7]=[C;H0;+0:8](-[*:9])-[CH2;+0:10]-[CH;+0:11]=[CH;+0:12]-1.[H+;H0:13].[O;H0;+0:14]=[O;H0;+0:15]>>[*:1]-[C;H0;+0:2](-[*:3])(-[*:4])-[OH;+0:14].[*:5]-[n+;H0:6]1:[cH;+0:7]:[c;H0;+0:8](-[*:9]):[cH;+0:10]:[cH;+0:11]:[cH;+0:12]:1.[OH2;+0:15] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Metabolism of vitamin D by human microsomal CYP2R1. | Shinkyo R, Sakaki T, Kamakura M, Ohta M, Inouye K | 2004 Nov 5 | 15465040 |
| Vitamin D 25-hydroxylase - Four decades of searching, are we there yet? | Zhu J, DeLuca HF | 2012 Jul 1 | 22310641 |
| Structural analysis of CYP2R1 in complex with vitamin D3. | Strushkevich N, Usanov SA, Plotnikov AN, Jones G, Park HW | 2008 Jun 27 | 18511070 |
| De-orphanization of cytochrome P450 2R1: a microsomal vitamin D 25-hydroxilase. | Cheng JB, Motola DL, Mangelsdorf DJ, Russell DW | 2003 Sep 26 | 12867411 |