EC number:1.14.14.25

Enzyme

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     1. Oxidoreductases
        1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
            1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
ID:1.14.14.25
Description:Cholesterol 24-hydroxylase.
Alternative Name: Cytochrome P450 46A1.
CYP46A1.
Cholesterol 24S-hydroxylase.
Cholesterol 24-monooxygenase.
Prosite: PDOC00081;
PDB:
PDBScop
Cath: 1.10.630.10;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 1.14.14.25
BRENDA Enzyme Link: BRENDA 1.14.14.25
KEGG Enzyme Link: KEGG1.14.14.25
BioCyc Enzyme Link: BioCyc 1.14.14.25
ExPASy Enzyme Link: ExPASy1.14.14.25
EC2PDB Enzyme Link: EC2PDB 1.14.14.25
ExplorEnz Enzyme Link: ExplorEnz 1.14.14.25
PRIAM enzyme-specific profiles Link: PRIAM 1.14.14.25
IntEnz Enzyme Link: IntEnz 1.14.14.25
MEDLINE Enzyme Link: MEDLINE 1.14.14.25

EC number:1.14.14.25

MSA:

1.14.14.25;
Phylogenetic Tree:

1.14.14.25;
Uniprot:
M-CSA:
RHEA:22716 cholesterol + O2 + reduced [NADPH--hemoprotein reductase] = (24S)-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RULE(radius=1) [*:1]-[CH2;+0:2]-[*:3].[*:4]-[N;H0;+0:5]1-[*:6]:[*:7]-[NH;+0:8]-[c;H0;+0:9](:[*:10]):[c;H0;+0:11]-1:[nH;+0:12]:[*:13].[O;H0;+0:14]=[O;H0;+0:15]>>[*:1]-[CH;+0:2](-[*:3])-[OH;+0:14].[*:4]-[n;H0;+0:5]1:[*:6]:[*:7]:[n;H0;+0:8]:[c;H0;+0:9](:[*:10])-[c;H0;+0:11]:1:[n;H0;+0:12]:[*:13].[OH2;+0:15]
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References

TitleAuthorsDatePubMed ID
The enzymes, regulation, and genetics of bile acid synthesis.Russell DW200312543708
Crystal structures of substrate-bound and substrate-free cytochrome P450 46A1, the principal cholesterol hydroxylase in the brain.Mast N, White MA, Bjorkhem I, Johnson EF, Stout CD, Pikuleva IA2008 Jul 1518621681
Broad substrate specificity of human cytochrome P450 46A1 which initiates cholesterol degradation in the brain.Mast N, Norcross R, Andersson U, Shou M, Nakayama K, Bjorkhem I, Pikuleva IA2003 Dec 914640697
cDNA cloning of cholesterol 24-hydroxylase, a mediator of cholesterol homeostasis in the brain.Lund EG, Guileyardo JM, Russell DW1999 Jun 2210377398