EC number:1.14.14.26
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen |
| 1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor |
| ID: | 1.14.14.26 | ||
|---|---|---|---|
| Description: | 24-hydroxycholesterol 7-alpha-hydroxylase. | ||
| Alternative Name: |
24-hydroxycholesterol 7-alpha-monooxygenase. | ||
| Prosite: | PDOC00081; | ||
| PDB: |
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3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.14.14.26 |
| BRENDA Enzyme Link: | BRENDA 1.14.14.26 |
| KEGG Enzyme Link: | KEGG1.14.14.26 |
| BioCyc Enzyme Link: | BioCyc 1.14.14.26 |
| ExPASy Enzyme Link: | ExPASy1.14.14.26 |
| EC2PDB Enzyme Link: | EC2PDB 1.14.14.26 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.14.14.26 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.14.14.26 |
| IntEnz Enzyme Link: | IntEnz 1.14.14.26 |
| MEDLINE Enzyme Link: | MEDLINE 1.14.14.26 |
EC number:1.14.14.26
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:46124 | (24S)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] = (24S)-7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[*:3].[*:4]-[N;H0;+0:5]1-[*:6]:[*:7]-[NH;+0:8]-[c;H0;+0:9](:[*:10]):[c;H0;+0:11]-1:[nH;+0:12]:[*:13].[O;H0;+0:14]=[O;H0;+0:15]>>[*:1]-[CH;+0:2](-[*:3])-[OH;+0:14].[*:4]-[n;H0;+0:5]1:[*:6]:[*:7]:[n;H0;+0:8]:[c;H0;+0:9](:[*:10])-[c;H0;+0:11]:1:[n;H0;+0:12]:[*:13].[OH2;+0:15] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| 24-hydroxycholesterol is a substrate for hepatic cholesterol 7alpha-hydroxylase (CYP7A). | Norlin M, Toll A, Björkhem I, Wikvall K | 2000 Oct | 11013305 |
| Expression cloning of an oxysterol 7alpha-hydroxylase selective for 24-hydroxycholesterol. | Li-Hawkins J, Lund EG, Bronson AD, Russell DW | 2000 Jun 2 | 10748047 |
| The bile acid synthetic gene 3beta-hydroxy-Delta(5)-C(27)-steroid oxidoreductase is mutated in progressive intrahepatic cholestasis. | Schwarz M, Wright AC, Davis DL, Nazer H, Björkhem I, Russell DW | 2000 Nov | 11067870 |
| Genetic, anatomic, and clinical determinants of human serum sterol and vitamin D levels. | Stiles AR, Kozlitina J, Thompson BM, McDonald JG, King KS, Russell DW | 2014 Sep 23 | 25201972 |