EC number:1.14.14.50
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen |
| 1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor |
| ID: | 1.14.14.50 |
|---|---|
| Description: | Tabersonine 3-oxygenase. |
| Alternative Name: |
T3O. CYP71D1V2. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.14.14.50 |
| BRENDA Enzyme Link: | BRENDA 1.14.14.50 |
| KEGG Enzyme Link: | KEGG1.14.14.50 |
| BioCyc Enzyme Link: | BioCyc 1.14.14.50 |
| ExPASy Enzyme Link: | ExPASy1.14.14.50 |
| EC2PDB Enzyme Link: | EC2PDB 1.14.14.50 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.14.14.50 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.14.14.50 |
| IntEnz Enzyme Link: | IntEnz 1.14.14.50 |
| MEDLINE Enzyme Link: | MEDLINE 1.14.14.50 |
EC number:1.14.14.50
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:55024 | O2 + reduced [NADPH--hemoprotein reductase] + tabersonine = (3R)-1,2-didehydro-3-hydroxy-2,3-dihydrotabersonine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] |
| RULE(radius=1) | [*:1]-[C;H0;+0:2](-[*:3])=[C;H0;+0:4](-[*:5])-[NH;+0:6]-[*:7].[*:8]-[N;H0;+0:9]1-[*:10]:[*:11]-[NH;+0:12]-[c;H0;+0:13](:[*:14]):[c;H0;+0:15]-1:[nH;+0:16]:[*:17].[O;H0;+0:18]=[O;H0;+0:19]>>[*:1]-[C;H0;+0:2](-[*:3])(-[OH;+0:18])-[C;H0;+0:4](-[*:5])=[N;H0;+0:6]-[*:7].[*:8]-[n;H0;+0:9]1:[*:10]:[*:11]:[n;H0;+0:12]:[c;H0;+0:13](:[*:14])-[c;H0;+0:15]:1:[n;H0;+0:16]:[*:17].[OH2;+0:19] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Completion of the seven-step pathway from tabersonine to the anticancer drug precursor vindoline and its assembly in yeast. | Qu Y, Easson ML, Froese J, Simionescu R, Hudlicky T, De Luca V | 2015 May 12 | 25918424 |
| RHEA:52480 | 16-methoxytabersonine + O2 + reduced [NADPH--hemoprotein reductase] = (3R)-1,2-didehydro-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] |
| RULE(radius=1) | [*:1]-[C;H0;+0:2](-[*:3])=[C;H0;+0:4](-[*:5])-[NH;+0:6]-[*:7].[*:8]-[N;H0;+0:9]1-[*:10]:[*:11]-[NH;+0:12]-[c;H0;+0:13](:[*:14]):[c;H0;+0:15]-1:[nH;+0:16]:[*:17].[O;H0;+0:18]=[O;H0;+0:19]>>[*:1]-[C;H0;+0:2](-[*:3])(-[OH;+0:18])-[C;H0;+0:4](-[*:5])=[N;H0;+0:6]-[*:7].[*:8]-[n;H0;+0:9]1:[*:10]:[*:11]:[n;H0;+0:12]:[c;H0;+0:13](:[*:14])-[c;H0;+0:15]:1:[n;H0;+0:16]:[*:17].[OH2;+0:19] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Completion of the seven-step pathway from tabersonine to the anticancer drug precursor vindoline and its assembly in yeast. | Qu Y, Easson ML, Froese J, Simionescu R, Hudlicky T, De Luca V | 2015 May 12 | 25918424 |