EC number:1.14.14.55

Enzyme

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     1. Oxidoreductases
        1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
            1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
ID:1.14.14.55
Description:Quinine 3-monooxygenase.
Alternative Name: Quinine 3-hydroxylase.
Nifedipine oxidase.
CYP3A4.
Prosite: PDOC00081;
PDB:
PDBScop

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 1.14.14.55
BRENDA Enzyme Link: BRENDA 1.14.14.55
KEGG Enzyme Link: KEGG1.14.14.55
BioCyc Enzyme Link: BioCyc 1.14.14.55
ExPASy Enzyme Link: ExPASy1.14.14.55
EC2PDB Enzyme Link: EC2PDB 1.14.14.55
ExplorEnz Enzyme Link: ExplorEnz 1.14.14.55
PRIAM enzyme-specific profiles Link: PRIAM 1.14.14.55
IntEnz Enzyme Link: IntEnz 1.14.14.55
MEDLINE Enzyme Link: MEDLINE 1.14.14.55

EC number:1.14.14.55

MSA:

1.14.14.55;
Phylogenetic Tree:

1.14.14.55;
Uniprot:
M-CSA:
RHEA:20149 O2 + quinine + reduced [NADPH--hemoprotein reductase] = 3-hydroxyquinine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RULE(radius=1) [*:1]-[CH;+0:2](-[*:3])-[*:4].[*:5]-[N;H0;+0:6]1-[CH;+0:7]=[C;H0;+0:8](-[*:9])-[CH2;+0:10]-[CH;+0:11]=[CH;+0:12]-1.[H+;H0:13].[O;H0;+0:14]=[O;H0;+0:15]>>[*:1]-[C;H0;+0:2](-[*:3])(-[*:4])-[OH;+0:14].[*:5]-[n+;H0:6]1:[cH;+0:7]:[c;H0;+0:8](-[*:9]):[cH;+0:10]:[cH;+0:11]:[cH;+0:12]:1.[OH2;+0:15]
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References

TitleAuthorsDatePubMed ID
Oxidation of 1,8-cineole, the monoterpene cyclic ether originated from eucalyptus polybractea, by cytochrome P450 3A enzymes in rat and human liver microsomes.Miyazawa M, Shindo M, Shimada T2001 Feb11159812