EC number:1.14.14.56
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen |
| 1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor |
| ID: | 1.14.14.56 |
|---|---|
| Description: | 1,8-cineole 2-exo-monooxygenase. |
| Alternative Name: |
CYP3A4. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.14.14.56 |
| BRENDA Enzyme Link: | BRENDA 1.14.14.56 |
| KEGG Enzyme Link: | KEGG1.14.14.56 |
| BioCyc Enzyme Link: | BioCyc 1.14.14.56 |
| ExPASy Enzyme Link: | ExPASy1.14.14.56 |
| EC2PDB Enzyme Link: | EC2PDB 1.14.14.56 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.14.14.56 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.14.14.56 |
| IntEnz Enzyme Link: | IntEnz 1.14.14.56 |
| MEDLINE Enzyme Link: | MEDLINE 1.14.14.56 |
EC number:1.14.14.56
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:32895 | 1,8-cineole + O2 + reduced [NADPH--hemoprotein reductase] = 2-exo-hydroxy-1,8-cineole + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[*:3].[*:4]-[N;H0;+0:5]1-[CH;+0:6]=[C;H0;+0:7](-[*:8])-[CH2;+0:9]-[CH;+0:10]=[CH;+0:11]-1.[H+;H0:12].[O;H0;+0:13]=[O;H0;+0:14]>>[*:1]-[CH;+0:2](-[*:3])-[OH;+0:13].[*:4]-[n+;H0:5]1:[cH;+0:6]:[c;H0;+0:7](-[*:8]):[cH;+0:9]:[cH;+0:10]:[cH;+0:11]:1.[OH2;+0:14] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Oxidation of 1,8-cineole, the monoterpene cyclic ether originated from eucalyptus polybractea, by cytochrome P450 3A enzymes in rat and human liver microsomes. | Miyazawa M, Shindo M, Shimada T | 2001 Feb | 11159812 |
| The critical role of substrate-protein hydrogen bonding in the control of regioselective hydroxylation in p450cin. | Meharenna YT, Slessor KE, Cavaignac SM, Poulos TL, De Voss JJ | 2008 Apr 18 | 18270198 |
| Cytochrome P450(cin) (CYP176A), isolation, expression, and characterization. | Hawkes DB, Adams GW, Burlingame AL, Ortiz de Montellano PR, De Voss JJ | 2002 Aug 2 | 12016226 |
| Roles of cytochrome P450 3A enzymes in the 2-hydroxylation of 1,4-cineole, a monoterpene cyclic ether, by rat and human liver microsomes. | Miyazawa M, Shindo M, Shimada T | 2001 Oct | 11695850 |