EC number:1.14.14.61
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen |
| 1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor |
| ID: | 1.14.14.61 |
|---|---|
| Description: | Carnosic acid synthase. |
| Alternative Name: |
CYP76AK8. CYP76AK7. CYP76AK6. |
3D structure
Click one PDB to see exact 3D structure provided by NGL.
Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.References
External Links
| UniProtKB Enzyme Link: | UniProtKB 1.14.14.61 |
| BRENDA Enzyme Link: | BRENDA 1.14.14.61 |
| KEGG Enzyme Link: | KEGG1.14.14.61 |
| BioCyc Enzyme Link: | BioCyc 1.14.14.61 |
| ExPASy Enzyme Link: | ExPASy1.14.14.61 |
| EC2PDB Enzyme Link: | EC2PDB 1.14.14.61 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.14.14.61 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.14.14.61 |
| IntEnz Enzyme Link: | IntEnz 1.14.14.61 |
| MEDLINE Enzyme Link: | MEDLINE 1.14.14.61 |
EC number:1.14.14.61
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:55432 | 11-hydroxyferruginol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = carnosate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] |
| RULE(radius=1) | [*:1]-[CH3;+0:2].[*:3]-[N;H0;+0:4]1-[*:5]:[*:6]-[NH;+0:7]-[c;H0;+0:8](:[*:9]):[c;H0;+0:10]-1:[nH;+0:11]:[*:12].[*:13]:[nH;+0:14]:[c;H0;+0:15]1:[c;H0;+0:16](:[*:17])-[NH;+0:18]-[*:19]:[*:20]-[N;H0;+0:21]-1-[*:22].[*:23]:[nH;+0:24]:[c;H0;+0:25]1:[c;H0;+0:26](:[*:27])-[NH;+0:28]-[*:29]:[*:30]-[N;H0;+0:31]-1-[*:32].[O;H0;+0:33]=[O;H0;+0:34].[O;H0;+0:35]=[O;H0;+0:36].[O;H0;+0:37]=[O;H0;+0:38]>>[*:1]-[C;H0;+0:2](=[O;H0;+0:33])-[OH;+0:34].[*:3]-[n;H0;+0:4]1:[*:5]:[*:6]:[n;H0;+0:7]:[c;H0;+0:8](:[*:9])-[c;H0;+0:10]:1:[n;H0;+0:11]:[*:12].[*:13]:[n;H0;+0:14]:[c;H0;+0:15]1:[n;H0;+0:21](-[*:22]):[*:20]:[*:19]:[n;H0;+0:18]:[c;H0;+0:16]-1:[*:17].[*:23]:[n;H0;+0:24]:[c;H0;+0:25]1:[n;H0;+0:31](-[*:32]):[*:30]:[*:29]:[n;H0;+0:28]:[c;H0;+0:26]-1:[*:27].[OH2;+0:35].[OH2;+0:36].[OH2;+0:37].[OH2;+0:38] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Elucidation of the biosynthesis of carnosic acid and its reconstitution in yeast. | Scheler U, Brandt W, Porzel A, Rothe K, Manzano D, Božić D, Papaefthimiou D, Balcke GU, Henning A, Lohse S, Marillonnet S, Kanellis AK, Ferrer A, Tissier A | 2016 Oct 5 | 27703160 |
| Carnosic acid biosynthesis elucidated by a synthetic biology platform. | Ignea C, Athanasakoglou A, Ioannou E, Georgantea P, Trikka FA, Loupassaki S, Roussis V, Makris AM, Kampranis SC | 2016 Mar 29 | 26976595 |