EC number:1.14.14.65
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen |
| 1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor |
| ID: | 1.14.14.65 |
|---|---|
| Description: | Sugiol synthase. |
| Alternative Name: |
CYP76AH3. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.14.14.65 |
| BRENDA Enzyme Link: | BRENDA 1.14.14.65 |
| KEGG Enzyme Link: | KEGG1.14.14.65 |
| BioCyc Enzyme Link: | BioCyc 1.14.14.65 |
| ExPASy Enzyme Link: | ExPASy1.14.14.65 |
| EC2PDB Enzyme Link: | EC2PDB 1.14.14.65 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.14.14.65 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.14.14.65 |
| IntEnz Enzyme Link: | IntEnz 1.14.14.65 |
| MEDLINE Enzyme Link: | MEDLINE 1.14.14.65 |
EC number:1.14.14.65
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:55460 | 11-hydroxyferruginol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = 11-hydroxysugiol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[*:3].[*:4]-[N;H0;+0:5]1-[*:6]:[*:7]-[NH;+0:8]-[c;H0;+0:9](:[*:10]):[c;H0;+0:11]-1:[nH;+0:12]:[*:13].[*:14]:[nH;+0:15]:[c;H0;+0:16]1:[c;H0;+0:17](:[*:18])-[NH;+0:19]-[*:20]:[*:21]-[N;H0;+0:22]-1-[*:23].[O;H0;+0:24]=[O;H0;+0:25].[O;H0;+0:26]=[O;H0;+0:27]>>[*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:24].[*:4]-[n;H0;+0:5]1:[*:6]:[*:7]:[n;H0;+0:8]:[c;H0;+0:9](:[*:10])-[c;H0;+0:11]:1:[n;H0;+0:12]:[*:13].[*:14]:[n;H0;+0:15]:[c;H0;+0:16]1:[n;H0;+0:22](-[*:23]):[*:21]:[*:20]:[n;H0;+0:19]:[c;H0;+0:17]-1:[*:18].[OH2;+0:25].[OH2;+0:26].[OH2;+0:27] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Cytochrome P450 promiscuity leads to a bifurcating biosynthetic pathway for tanshinones. | Guo J, Ma X, Cai Y, Ma Y, Zhan Z, Zhou YJ, Liu W, Guan M, Yang J, Cui G, Kang L, Yang L, Shen Y, Tang J, Lin H, Ma X, Jin B, Liu Z, Peters RJ, Zhao ZK, Huang L | 2016 Apr | 26682704 |
| RHEA:55456 | ferruginol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] + sugiol |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[*:3].[*:4]-[N;H0;+0:5]1-[*:6]:[*:7]-[NH;+0:8]-[c;H0;+0:9](:[*:10]):[c;H0;+0:11]-1:[nH;+0:12]:[*:13].[*:14]:[nH;+0:15]:[c;H0;+0:16]1:[c;H0;+0:17](:[*:18])-[NH;+0:19]-[*:20]:[*:21]-[N;H0;+0:22]-1-[*:23].[O;H0;+0:24]=[O;H0;+0:25].[O;H0;+0:26]=[O;H0;+0:27]>>[*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:24].[*:4]-[n;H0;+0:5]1:[*:6]:[*:7]:[n;H0;+0:8]:[c;H0;+0:9](:[*:10])-[c;H0;+0:11]:1:[n;H0;+0:12]:[*:13].[*:14]:[n;H0;+0:15]:[c;H0;+0:16]1:[n;H0;+0:22](-[*:23]):[*:21]:[*:20]:[n;H0;+0:19]:[c;H0;+0:17]-1:[*:18].[OH2;+0:25].[OH2;+0:26].[OH2;+0:27] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Cytochrome P450 promiscuity leads to a bifurcating biosynthetic pathway for tanshinones. | Guo J, Ma X, Cai Y, Ma Y, Zhan Z, Zhou YJ, Liu W, Guan M, Yang J, Cui G, Kang L, Yang L, Shen Y, Tang J, Lin H, Ma X, Jin B, Liu Z, Peters RJ, Zhao ZK, Huang L | 2016 Apr | 26682704 |