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1. Oxidoreductases

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor

ID:	1.14.14.75
Description:	Fenbendazole monooxygenase (4'-hydroxylating).
Alternative Name:	CYP2C19.

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UniProtKB Enzyme Link:	UniProtKB 1.14.14.75
BRENDA Enzyme Link:	BRENDA 1.14.14.75
KEGG Enzyme Link:	KEGG1.14.14.75
BioCyc Enzyme Link:	BioCyc 1.14.14.75
ExPASy Enzyme Link:	ExPASy1.14.14.75
EC2PDB Enzyme Link:	EC2PDB 1.14.14.75
ExplorEnz Enzyme Link:	ExplorEnz 1.14.14.75
PRIAM enzyme-specific profiles Link:	PRIAM 1.14.14.75
IntEnz Enzyme Link:	IntEnz 1.14.14.75
MEDLINE Enzyme Link:	MEDLINE 1.14.14.75

RHEA:56292	fenbendazole + O2 + reduced [NADPH--hemoprotein reductase] = 4'-hydroxyfenbendazole + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RULE(radius=1)	[:1]-[N;H0;+0:2]1-[:3]:[:4]-[NH;+0:5]-[c;H0;+0:6](:[:7]):[c;H0;+0:8]-1:[nH;+0:9]:[:10].[:11]:[cH;+0:12]:[:13].[O;H0;+0:14]=[O;H0;+0:15]>>[:1]-[n;H0;+0:2]1:[:3]:[:4]:[n;H0;+0:5]:[c;H0;+0:6](:[:7])-[c;H0;+0:8]:1:[n;H0;+0:9]:[:10].[:11]:[c;H0;+0:12](:[:13])-[OH;+0:14].[OH2;+0:15]
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Core-to-Core	More

Title	Authors	Date	PubMed ID
CYP2J2 and CYP2C19 are the major enzymes responsible for metabolism of albendazole and fenbendazole in human liver microsomes and recombinant P450 assay systems.	Wu Z, Lee D, Joo J, Shin JH, Kang W, Oh S, Lee DY, Lee SJ, Yea SS, Lee HS, Lee T, Liu KH	2013 Nov	23959307