EC number:1.14.14.79
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen |
| 1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor |
| ID: | 1.14.14.79 |
|---|---|
| Description: | Docosahexaenoic acid omega-hydroxylase. |
| Alternative Name: |
CYP4V2. CYP4F3B. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.14.14.79 |
| BRENDA Enzyme Link: | BRENDA 1.14.14.79 |
| KEGG Enzyme Link: | KEGG1.14.14.79 |
| BioCyc Enzyme Link: | BioCyc 1.14.14.79 |
| ExPASy Enzyme Link: | ExPASy1.14.14.79 |
| EC2PDB Enzyme Link: | EC2PDB 1.14.14.79 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.14.14.79 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.14.14.79 |
| IntEnz Enzyme Link: | IntEnz 1.14.14.79 |
| MEDLINE Enzyme Link: | MEDLINE 1.14.14.79 |
EC number:1.14.14.79
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:40155 | (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 22-hydroxy-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] |
| RULE(radius=1) | [*:1]-[CH3;+0:2].[*:3]-[N;H0;+0:4]1-[CH;+0:5]=[C;H0;+0:6](-[*:7])-[CH2;+0:8]-[CH;+0:9]=[CH;+0:10]-1.[O;H0;+0:11]=[O;H0;+0:12]>>[*:1]-[CH2;+0:2]-[OH;+0:11].[*:3]-[n+;H0:4]1:[cH;+0:5]:[c;H0;+0:6](-[*:7]):[cH;+0:8]:[cH;+0:9]:[cH;+0:10]:1.[OH2;+0:12] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| CYP4V2 in Bietti's crystalline dystrophy: ocular localization, metabolism of ω-3-polyunsaturated fatty acids, and functional deficit of the p.H331P variant. | Nakano M, Kelly EJ, Wiek C, Hanenberg H, Rettie AE | 2012 Oct | 22772592 |
| Cytochromes P450 from family 4 are the main omega hydroxylating enzymes in humans: CYP4F3B is the prominent player in PUFA metabolism. | Fer M, Corcos L, Dréano Y, Plée-Gautier E, Salaün JP, Berthou F, Amet Y | 2008 Nov | 18577768 |
| Oxygenation of omega-3 fatty acids by human cytochrome P450 4F3B: effect on 20-hydroxyeicosatetraenoic acid production. | Harmon SD, Fang X, Kaduce TL, Hu S, Raj Gopal V, Falck JR, Spector AA | 2006 Sep | 16820285 |