EC number:1.14.14.80
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen |
| 1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor |
| ID: | 1.14.14.80 |
|---|---|
| Description: | Long-chain fatty acid omega-monooxygenase. |
| Alternative Name: |
CYP86A. CYP704B1. CYP52M1. CYP4A. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.14.14.80 |
| BRENDA Enzyme Link: | BRENDA 1.14.14.80 |
| KEGG Enzyme Link: | KEGG1.14.14.80 |
| BioCyc Enzyme Link: | BioCyc 1.14.14.80 |
| ExPASy Enzyme Link: | ExPASy1.14.14.80 |
| EC2PDB Enzyme Link: | EC2PDB 1.14.14.80 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.14.14.80 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.14.14.80 |
| IntEnz Enzyme Link: | IntEnz 1.14.14.80 |
| MEDLINE Enzyme Link: | MEDLINE 1.14.14.80 |
EC number:1.14.14.80
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:40199 | hexadecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 16-hydroxyhexadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] |
| RULE(radius=1) | [*:1]-[CH3;+0:2].[*:3]-[N;H0;+0:4]1-[CH;+0:5]=[C;H0;+0:6](-[*:7])-[CH2;+0:8]-[CH;+0:9]=[CH;+0:10]-1.[H+;H0:11].[O;H0;+0:12]=[O;H0;+0:13]>>[*:1]-[CH2;+0:2]-[OH;+0:12].[*:3]-[n+;H0:4]1:[cH;+0:5]:[c;H0;+0:6](-[*:7]):[cH;+0:8]:[cH;+0:9]:[cH;+0:10]:1.[OH2;+0:13] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Biochemical and structural characterization of CYP124: a methyl-branched lipid omega-hydroxylase from Mycobacterium tuberculosis. | Johnston JB, Kells PM, Podust LM, Ortiz de Montellano PR | 2009 Dec 8 | 19933331 |
| Expression and characterization of CYP52 genes involved in the biosynthesis of sophorolipid and alkane metabolism from Starmerella bombicola. | Huang FC, Peter A, Schwab W | 2014 Jan | 24242247 |
| CYP704B1 is a long-chain fatty acid omega-hydroxylase essential for sporopollenin synthesis in pollen of Arabidopsis. | Dobritsa AA, Shrestha J, Morant M, Pinot F, Matsuno M, Swanson R, Møller BL, Preuss D | 2009 Oct | 19700560 |
| Expression and characterization of CYP4V2 as a fatty acid omega-hydroxylase. | Nakano M, Kelly EJ, Rettie AE | 2009 Nov | 19661213 |
| RHEA:41728 | (9Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase] = 18-hydroxy-(9Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] |
| RULE(radius=1) | [*:1]-[CH3;+0:2].[*:3]-[N;H0;+0:4]1-[CH;+0:5]=[C;H0;+0:6](-[*:7])-[CH2;+0:8]-[CH;+0:9]=[CH;+0:10]-1.[H+;H0:11].[O;H0;+0:12]=[O;H0;+0:13]>>[*:1]-[CH2;+0:2]-[OH;+0:12].[*:3]-[n+;H0:4]1:[cH;+0:5]:[c;H0;+0:6](-[*:7]):[cH;+0:8]:[cH;+0:9]:[cH;+0:10]:1.[OH2;+0:13] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Structural determination of the substrate specificities and regioselectivities of the rat and human fatty acid omega-hydroxylases. | Hoch U, Zhang Z, Kroetz DL, Ortiz de Montellano PR | 2000 Jan 1 | 10620324 |
| CYP704B1 is a long-chain fatty acid omega-hydroxylase essential for sporopollenin synthesis in pollen of Arabidopsis. | Dobritsa AA, Shrestha J, Morant M, Pinot F, Matsuno M, Swanson R, Møller BL, Preuss D | 2009 Oct | 19700560 |
| RHEA:46356 | O2 + octadecanoate + reduced [NADPH--hemoprotein reductase] = 18-hydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] |
| RULE(radius=1) | [*:1]-[CH3;+0:2].[*:3]-[N;H0;+0:4]1-[CH;+0:5]=[C;H0;+0:6](-[*:7])-[CH2;+0:8]-[CH;+0:9]=[CH;+0:10]-1.[H+;H0:11].[O;H0;+0:12]=[O;H0;+0:13]>>[*:1]-[CH2;+0:2]-[OH;+0:12].[*:3]-[n+;H0:4]1:[cH;+0:5]:[c;H0;+0:6](-[*:7]):[cH;+0:8]:[cH;+0:9]:[cH;+0:10]:1.[OH2;+0:13] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Identification of CYP4A11 as the major lauric acid omega-hydroxylase in human liver microsomes. | Powell PK, Wolf I, Lasker JM | 1996 Nov 1 | 8914854 |
| Expression and characterization of CYP52 genes involved in the biosynthesis of sophorolipid and alkane metabolism from Starmerella bombicola. | Huang FC, Peter A, Schwab W | 2014 Jan | 24242247 |
| RHEA:56748 | an omega-methyl-long-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an omega-hydroxy-long-chain fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] |
| RULE(radius=1) | [*:1]-[N;H0;+0:2]1-[*:3]:[*:4]-[NH;+0:5]-[c;H0;+0:6](:[*:7]):[c;H0;+0:8]-1:[nH;+0:9]:[*:10].[O;H0;+0:11]=[O;H0;+0:12]>>[*:1]-[n;H0;+0:2]1:[*:3]:[*:4]:[n;H0;+0:5]:[c;H0;+0:6](:[*:7])-[c;H0;+0:8]:1:[n;H0;+0:9]:[*:10].[OH2;+0:11] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| CYP86A1 from Arabidopsis thaliana encodes a cytochrome P450-dependent fatty acid omega-hydroxylase. | Benveniste I, Tijet N, Adas F, Philipps G, Salaün JP, Durst F | 1998 Feb 24 | 9500987 |
| Structural determination of the substrate specificities and regioselectivities of the rat and human fatty acid omega-hydroxylases. | Hoch U, Zhang Z, Kroetz DL, Ortiz de Montellano PR | 2000 Jan 1 | 10620324 |
| Expression and characterization of CYP52 genes involved in the biosynthesis of sophorolipid and alkane metabolism from Starmerella bombicola. | Huang FC, Peter A, Schwab W | 2014 Jan | 24242247 |
| CYP704B1 is a long-chain fatty acid omega-hydroxylase essential for sporopollenin synthesis in pollen of Arabidopsis. | Dobritsa AA, Shrestha J, Morant M, Pinot F, Matsuno M, Swanson R, Møller BL, Preuss D | 2009 Oct | 19700560 |