EC number:1.14.14.81
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen |
| 1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor |
| ID: | 1.14.14.81 | ||
|---|---|---|---|
| Description: | Flavonoid 3',5'-hydroxylase. | ||
| Alternative Name: |
F3'5'H. F3',5'H. | ||
| Prosite: | PDOC00081; | ||
| PDB: |
|
3D structure
Click one PDB to see exact 3D structure provided by NGL.
Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.References
External Links
| UniProtKB Enzyme Link: | UniProtKB 1.14.14.81 |
| BRENDA Enzyme Link: | BRENDA 1.14.14.81 |
| KEGG Enzyme Link: | KEGG1.14.14.81 |
| BioCyc Enzyme Link: | BioCyc 1.14.14.81 |
| ExPASy Enzyme Link: | ExPASy1.14.14.81 |
| EC2PDB Enzyme Link: | EC2PDB 1.14.14.81 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.14.14.81 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.14.14.81 |
| IntEnz Enzyme Link: | IntEnz 1.14.14.81 |
| MEDLINE Enzyme Link: | MEDLINE 1.14.14.81 |
EC number:1.14.14.81
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:55448 | a 3',5'-unsubstituted flavanone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = a 3',5'-dihydroxyflavanone + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase] |
| RULE(radius=1) | [*:1]-[N;H0;+0:2]1-[*:3]:[*:4]-[NH;+0:5]-[c;H0;+0:6](:[*:7]):[c;H0;+0:8]-1:[nH;+0:9]:[*:10].[*:11]:[cH;+0:12]:[*:13]:[cH;+0:14]:[*:15].[*:16]:[nH;+0:17]:[c;H0;+0:18]1:[c;H0;+0:19](:[*:20])-[NH;+0:21]-[*:22]:[*:23]-[N;H0;+0:24]-1-[*:25].[O;H0;+0:26]=[O;H0;+0:27].[O;H0;+0:28]=[O;H0;+0:29]>>[*:1]-[n;H0;+0:2]1:[*:3]:[*:4]:[n;H0;+0:5]:[c;H0;+0:6](:[*:7])-[c;H0;+0:8]:1:[n;H0;+0:9]:[*:10].[*:11]:[c;H0;+0:12](-[OH;+0:26]):[*:13]:[c;H0;+0:14](:[*:15])-[OH;+0:27].[*:16]:[n;H0;+0:17]:[c;H0;+0:18]1:[n;H0;+0:24](-[*:25]):[*:23]:[*:22]:[n;H0;+0:21]:[c;H0;+0:19]-1:[*:20].[OH2;+0:28].[OH2;+0:29] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| A cytochrome b5 is required for full activity of flavonoid 3', 5'-hydroxylase, a cytochrome P450 involved in the formation of blue flower colors. | de Vetten N, ter Horst J, van Schaik HP, de Boer A, Mol J, Koes R | 1999 Jan 19 | 9892710 |
| Characterization of Flavonoid 3[prime],5[prime]-Hydroxylase in Microsomal Membrane Fraction of Petunia hybrida Flowers. | Menting J, Scopes RK, Stevenson TW | 1994 Oct | 12232356 |
| Expression of chimeric P450 genes encoding flavonoid-3', 5'-hydroxylase in transgenic tobacco and petunia plants(1). | Shimada Y, Nakano-Shimada R, Ohbayashi M, Okinaka Y, Kiyokawa S, Kikuchi Y | 1999 Nov 19 | 10567704 |