EC number:1.14.14.86
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen |
| 1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor |
| ID: | 1.14.14.86 | ||
|---|---|---|---|
| Description: | Ent-kaurene monooxygenase. | ||
| Alternative Name: |
Ent-kaurene oxidase. | ||
| Prosite: | PDOC00081; | ||
| PDB: |
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3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.14.14.86 |
| BRENDA Enzyme Link: | BRENDA 1.14.14.86 |
| KEGG Enzyme Link: | KEGG1.14.14.86 |
| BioCyc Enzyme Link: | BioCyc 1.14.14.86 |
| ExPASy Enzyme Link: | ExPASy1.14.14.86 |
| EC2PDB Enzyme Link: | EC2PDB 1.14.14.86 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.14.14.86 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.14.14.86 |
| IntEnz Enzyme Link: | IntEnz 1.14.14.86 |
| MEDLINE Enzyme Link: | MEDLINE 1.14.14.86 |
EC number:1.14.14.86
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:32323 | ent-kaur-16-ene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = ent-kaur-16-en-19-oate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] |
| RULE(radius=1) | [*:1]-[C;H0;+0:2]1=[CH;+0:3]-[N;H0;+0:4](-[*:5])-[CH;+0:6]=[CH;+0:7]-[CH2;+0:8]-1.[*:9]-[CH3;+0:10].[*:11]-[N;H0;+0:12]1-[CH;+0:13]=[C;H0;+0:14](-[*:15])-[CH2;+0:16]-[CH;+0:17]=[CH;+0:18]-1.[*:19]-[N;H0;+0:20]1-[CH;+0:21]=[C;H0;+0:22](-[*:23])-[CH2;+0:24]-[CH;+0:25]=[CH;+0:26]-1.[O;H0;+0:27]=[O;H0;+0:28].[O;H0;+0:29]=[O;H0;+0:30].[O;H0;+0:31]=[O;H0;+0:32]>>[*:9]-[C;H0;+0:10](=[O;H0;+0:27])-[OH;+0:28].[*:1]-[c;H0;+0:2]1:[cH;+0:3]:[n+;H0:4](-[*:5]):[cH;+0:6]:[cH;+0:7]:[cH;+0:8]:1.[*:11]-[n+;H0:12]1:[cH;+0:13]:[c;H0;+0:14](-[*:15]):[cH;+0:16]:[cH;+0:17]:[cH;+0:18]:1.[*:19]-[n+;H0:20]1:[cH;+0:21]:[c;H0;+0:22](-[*:23]):[cH;+0:24]:[cH;+0:25]:[cH;+0:26]:1.[OH2;+0:29].[OH2;+0:30].[OH2;+0:31].[OH2;+0:32] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Arabidopsis ent-kaurene oxidase catalyzes three steps of gibberellin biosynthesis. | Helliwell CA, Poole A, Peacock WJ, Dennis ES | 1999 Feb | 9952446 |
| A conformationally restricted uniconazole analogue as a specific inhibitor of rice ent-kaurene oxidase, CYP701A6. | Todoroki Y, Naiki K, Muramatsu T, Ohnishi T, Ueno K, Mizutani M, Hirai N | 2012 May 1 | 22487175 |
| CYP701A8: a rice ent-kaurene oxidase paralog diverted to more specialized diterpenoid metabolism. | Wang Q, Hillwig ML, Wu Y, Peters RJ | 2012 Mar | 22247270 |
| Characterization of ent-kaurene oxidase activity from Gibberella fujikuroi. | Ashman PJ, Mackenzie A, Bramley PM | 1990 Nov 9 | 2223832 |
| Purification of ent-kaurene oxidase from Gibberella fujikuroi and Cucurbita maxima. | Archer C, Ashman PJ, Hedden P, Bowyer JR, Bramley PM | 1992 May | 1397591 |