EC number:1.14.14.87
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen |
| 1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor |
| ID: | 1.14.14.87 |
|---|---|
| Description: | 2-hydroxyisoflavanone synthase. |
| Alternative Name: |
Isoflavonoid synthase. CYT93C. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.14.14.87 |
| BRENDA Enzyme Link: | BRENDA 1.14.14.87 |
| KEGG Enzyme Link: | KEGG1.14.14.87 |
| BioCyc Enzyme Link: | BioCyc 1.14.14.87 |
| ExPASy Enzyme Link: | ExPASy1.14.14.87 |
| EC2PDB Enzyme Link: | EC2PDB 1.14.14.87 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.14.14.87 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.14.14.87 |
| IntEnz Enzyme Link: | IntEnz 1.14.14.87 |
| MEDLINE Enzyme Link: | MEDLINE 1.14.14.87 |
EC number:1.14.14.87
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:35487 | (S)-naringenin + O2 + reduced [NADPH--hemoprotein reductase] = 2-hydroxy-2,3-dihydrogenistein + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[CH;+0:3](-[*:4])-[c;H0;+0:5](:[*:6]):[*:7].[*:8]-[N;H0;+0:9]1-[CH;+0:10]=[C;H0;+0:11](-[*:12])-[CH2;+0:13]-[CH;+0:14]=[CH;+0:15]-1.[H+;H0:16].[O;H0;+0:17]=[O;H0;+0:18]>>[*:1]-[CH;+0:2](-[CH;+0:3](-[*:4])-[OH;+0:18])-[c;H0;+0:5](:[*:6]):[*:7].[*:8]-[n+;H0:9]1:[cH;+0:10]:[c;H0;+0:11](-[*:12]):[cH;+0:13]:[cH;+0:14]:[cH;+0:15]:1.[OH2;+0:17] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Key amino acid residues required for aryl migration catalysed by the cytochrome P450 2-hydroxyisoflavanone synthase. | Sawada Y, Kinoshita K, Akashi T, Aoki T, Ayabe S | 2002 Sep | 12207646 |
| Molecular characterization of the enzyme catalyzing the aryl migration reaction of isoflavonoid biosynthesis in soybean. | Steele CL, Gijzen M, Qutob D, Dixon RA | 1999 Jul 1 | 10375412 |
| Enzymic synthesis of isoflavones. | Kochs G, Grisebach H | 1986 Mar 3 | 3956488 |
| Reaction mechanism of oxidative rearrangement of flavanone in isoflavone biosynthesis. | Hashim MF, Hakamatsuka T, Ebizuka Y, Sankawa U | 1990 Oct 1 | 2226805 |
| Multiple mutagenesis of P450 isoflavonoid synthase reveals a key active-site residue. | Sawada Y, Ayabe S | 2005 May 13 | 15809082 |
| RHEA:31723 | liquiritigenin + O2 + reduced [NADPH--hemoprotein reductase] = (2R,3S)-2,4',7-trihydroxyisoflavanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[CH;+0:3](-[*:4])-[c;H0;+0:5](:[*:6]):[*:7].[*:8]-[N;H0;+0:9]1-[CH;+0:10]=[C;H0;+0:11](-[*:12])-[CH2;+0:13]-[CH;+0:14]=[CH;+0:15]-1.[H+;H0:16].[O;H0;+0:17]=[O;H0;+0:18]>>[*:1]-[CH;+0:2](-[CH;+0:3](-[*:4])-[OH;+0:18])-[c;H0;+0:5](:[*:6]):[*:7].[*:8]-[n+;H0:9]1:[cH;+0:10]:[c;H0;+0:11](-[*:12]):[cH;+0:13]:[cH;+0:14]:[cH;+0:15]:1.[OH2;+0:17] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Key amino acid residues required for aryl migration catalysed by the cytochrome P450 2-hydroxyisoflavanone synthase. | Sawada Y, Kinoshita K, Akashi T, Aoki T, Ayabe S | 2002 Sep | 12207646 |
| Molecular characterization of the enzyme catalyzing the aryl migration reaction of isoflavonoid biosynthesis in soybean. | Steele CL, Gijzen M, Qutob D, Dixon RA | 1999 Jul 1 | 10375412 |
| Enzymic synthesis of isoflavones. | Kochs G, Grisebach H | 1986 Mar 3 | 3956488 |
| Reaction mechanism of oxidative rearrangement of flavanone in isoflavone biosynthesis. | Hashim MF, Hakamatsuka T, Ebizuka Y, Sankawa U | 1990 Oct 1 | 2226805 |
| Multiple mutagenesis of P450 isoflavonoid synthase reveals a key active-site residue. | Sawada Y, Ayabe S | 2005 May 13 | 15809082 |