EC number:1.14.14.94

Enzyme

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     1. Oxidoreductases
        1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
            1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
ID:1.14.14.94
Description:Leukotriene-B(4) 20-monooxygenase.
Alternative Name: LTB4 omega-hydroxylase.
LTB4 20-hydroxylase.
Leukotriene-B(4) 20-hydroxylase.
Leucotriene-B(4) omega-hydroxylase.
CYP4F3.
CYP4F2.
Prosite: PDOC00081;
PDB:
PDBScop

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 1.14.14.94
BRENDA Enzyme Link: BRENDA 1.14.14.94
KEGG Enzyme Link: KEGG1.14.14.94
BioCyc Enzyme Link: BioCyc 1.14.14.94
ExPASy Enzyme Link: ExPASy1.14.14.94
EC2PDB Enzyme Link: EC2PDB 1.14.14.94
ExplorEnz Enzyme Link: ExplorEnz 1.14.14.94
PRIAM enzyme-specific profiles Link: PRIAM 1.14.14.94
IntEnz Enzyme Link: IntEnz 1.14.14.94
MEDLINE Enzyme Link: MEDLINE 1.14.14.94

EC number:1.14.14.94

MSA:

1.14.14.94;
Phylogenetic Tree:

1.14.14.94;
Uniprot:
M-CSA:
RHEA:22176 leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RULE(radius=1) [*:1]-[CH3;+0:2].[*:3]-[N;H0;+0:4]1-[*:5]:[*:6]-[NH;+0:7]-[c;H0;+0:8](:[*:9]):[c;H0;+0:10]-1:[nH;+0:11]:[*:12].[O;H0;+0:13]=[O;H0;+0:14]>>[*:1]-[CH2;+0:2]-[OH;+0:13].[*:3]-[n;H0;+0:4]1:[*:5]:[*:6]:[n;H0;+0:7]:[c;H0;+0:8](:[*:9])-[c;H0;+0:10]:1:[n;H0;+0:11]:[*:12].[OH2;+0:14]
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References

TitleAuthorsDatePubMed ID
Role of human CYP4F2 in hepatic catabolism of the proinflammatory agent leukotriene B4.Jin R, Koop DR, Raucy JL, Lasker JM1998 Nov 19799565
Purification and characterization of recombinant human neutrophil leukotriene B4 omega-hydroxylase (cytochrome P450 4F3).Kikuta Y, Kusunose E, Sumimoto H, Mizukami Y, Takeshige K, Sakaki T, Yabusaki Y, Kusunose M1998 Jul 159675028
Human leukotriene B4 omega-hydroxylase (CYP4F3) gene: molecular cloning and chromosomal localization.Kikuta Y, Kato M, Yamashita Y, Miyauchi Y, Tanaka K, Kamada N, Kusunose M1998 Mar9539102
Protein expression, characterization, and regulation of CYP4F4 and CYP4F5 cloned from rat brain.Kawashima H, Kusunose E, Thompson CM, Strobel HW1997 Nov 19344476
Cloning and expression of a novel form of leukotriene B4 omega-hydroxylase from human liver.Kikuta Y, Kusunose E, Kondo T, Yamamoto S, Kinoshita H, Kusunose M1994 Jul 48026587
Altered leukotriene B4 metabolism in CYP4F18-deficient mice does not impact inflammation following renal ischemia.Winslow V, Vaivoda R, Vasilyev A, Dombkowski D, Douaidy K, Stark C, Drake J, Guilliams E, Choudhary D, Preffer F, Stoilov I, Christmas P2014 Jun24632148
Catalytic characterization and cytokine mediated regulation of cytochrome P450 4Fs in rat hepatocytes.Kalsotra A, Anakk S, Brommer CL, Kikuta Y, Morgan ET, Strobel HW2007 May 117418803
Functional polymorphism in human CYP4F2 decreases 20-HETE production.Stec DE, Roman RJ, Flasch A, Rieder MJ2007 Jun 1917341693
Expression and characterization of human cytochrome P450 4F11: Putative role in the metabolism of therapeutic drugs and eicosanoids.Kalsotra A, Turman CM, Kikuta Y, Strobel HW2004 Sep 1515364545
Catalytic activity and isoform-specific inhibition of rat cytochrome p450 4F enzymes.Xu F, Falck JR, Ortiz de Montellano PR, Kroetz DL2004 Mar14634044
Characterization of human liver leukotriene B(4) omega-hydroxylase P450 (CYP4F2).Kikuta Y, Kusunose E, Kusunose M2000 Jun10833273
Purification and characterization of recombinant rat hepatic CYP4F1.Kikuta Y, Kusunose E, Ito M, Kusunose M1999 Sep 1510486137