EC number:1.14.14.95

Enzyme

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     1. Oxidoreductases
        1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
            1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
ID:1.14.14.95
Description:Germacrene A hydroxylase.

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 1.14.14.95
BRENDA Enzyme Link: BRENDA 1.14.14.95
KEGG Enzyme Link: KEGG1.14.14.95
BioCyc Enzyme Link: BioCyc 1.14.14.95
ExPASy Enzyme Link: ExPASy1.14.14.95
EC2PDB Enzyme Link: EC2PDB 1.14.14.95
ExplorEnz Enzyme Link: ExplorEnz 1.14.14.95
PRIAM enzyme-specific profiles Link: PRIAM 1.14.14.95
IntEnz Enzyme Link: IntEnz 1.14.14.95
MEDLINE Enzyme Link: MEDLINE 1.14.14.95

EC number:1.14.14.95

MSA:

1.14.14.95;
Phylogenetic Tree:

1.14.14.95;
Uniprot:
M-CSA:
RHEA:30303 (+)-(R)-germacrene A + O2 + reduced [NADPH--hemoprotein reductase] = germacra-1(10),4,11(13)-trien-12-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RULE(radius=1) [*:1]-[CH3;+0:2].[*:3]-[N;H0;+0:4]1-[CH;+0:5]=[C;H0;+0:6](-[*:7])-[CH2;+0:8]-[CH;+0:9]=[CH;+0:10]-1.[H+;H0:11].[O;H0;+0:12]=[O;H0;+0:13]>>[*:1]-[CH2;+0:2]-[OH;+0:12].[*:3]-[n+;H0:4]1:[cH;+0:5]:[c;H0;+0:6](-[*:7]):[cH;+0:8]:[cH;+0:9]:[cH;+0:10]:1.[OH2;+0:13]
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References

TitleAuthorsDatePubMed ID
Biochemical conservation and evolution of germacrene A oxidase in asteraceae.Nguyen DT, Göpfert JC, Ikezawa N, Macnevin G, Kathiresan M, Conrad J, Spring O, Ro DK2010 May 2820351109
Biosynthesis of germacrene A carboxylic acid in chicory roots. Demonstration of a cytochrome P450 (+)-germacrene a hydroxylase and NADP+-dependent sesquiterpenoid dehydrogenase(s) involved in sesquiterpene lactone biosynthesis.de Kraker JW, Franssen MC, Dalm MC, de Groot A, Bouwmeester HJ2001 Apr11299372