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1. Oxidoreductases

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor

ID:

1.14.14.97

Description:

Methyltetrahydroprotoberberine 14-monooxygenase.

Alternative Name:

Methyltetrahydroprotoberberine 14-hydroxylase.
CYP82N4.
(S)-cis-N-methyltetrahydroprotoberberine-14-hydroxylase.

Prosite:

PDOC00081;

PDB:

PDB	Scop

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UniProtKB Enzyme Link:	UniProtKB 1.14.14.97
BRENDA Enzyme Link:	BRENDA 1.14.14.97
KEGG Enzyme Link:	KEGG1.14.14.97
BioCyc Enzyme Link:	BioCyc 1.14.14.97
ExPASy Enzyme Link:	ExPASy1.14.14.97
EC2PDB Enzyme Link:	EC2PDB 1.14.14.97
ExplorEnz Enzyme Link:	ExplorEnz 1.14.14.97
PRIAM enzyme-specific profiles Link:	PRIAM 1.14.14.97
IntEnz Enzyme Link:	IntEnz 1.14.14.97
MEDLINE Enzyme Link:	MEDLINE 1.14.14.97

RHEA:23684	(S)-N-methylcanadine + O2 + reduced [NADPH--hemoprotein reductase] = allocryptopine + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RULE(radius=1)	[:1]-[N+;H0:2](-[:3])(-[:4])-[CH;+0:5](-[:6])-[:7].[:8]-[N;H0;+0:9]1-[CH;+0:10]=[C;H0;+0:11](-[:12])-[CH2;+0:13]-[CH;+0:14]=[CH;+0:15]-1.[O;H0;+0:16]=[O;H0;+0:17]>>([:6]-[C;H0;+0:5](-[:7])=[O;H0;+0:16].[:1]-[N;H0;+0:2](-[:3])-[:4]).[:8]-[n+;H0:9]1:[cH;+0:10]:[c;H0;+0:11](-[:12]):[cH;+0:13]:[cH;+0:14]:[cH;+0:15]:1.[OH2;+0:17]
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Title	Authors	Date	PubMed ID
Isolation and characterization of a cDNA encoding (S)-cis-N-methylstylopine 14-hydroxylase from opium poppy, a key enzyme in sanguinarine biosynthesis.	Beaudoin GA, Facchini PJ	2013 Feb 15	23313486