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1. Oxidoreductases

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.15 With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor

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UniProtKB Enzyme Link:	UniProtKB 1.14.15.22
BRENDA Enzyme Link:	BRENDA 1.14.15.22
KEGG Enzyme Link:	KEGG1.14.15.22
BioCyc Enzyme Link:	BioCyc 1.14.15.22
ExPASy Enzyme Link:	ExPASy1.14.15.22
EC2PDB Enzyme Link:	EC2PDB 1.14.15.22
ExplorEnz Enzyme Link:	ExplorEnz 1.14.15.22
PRIAM enzyme-specific profiles Link:	PRIAM 1.14.15.22
IntEnz Enzyme Link:	IntEnz 1.14.15.22
MEDLINE Enzyme Link:	MEDLINE 1.14.15.22

RHEA:50700	calcidiol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = calcitriol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
RULE(radius=1)	[:1]-[CH2;+0:2]-[:3].[:4]-[Fe;H0;+0:5]-[:6].[:7]-[Fe;H0;+0:8]-[:9].[H+;H0:10].[H+;H0:11].[O;H0;+0:12]=[O;H0;+0:13]>>[:1]-[CH;+0:2](-[:3])-[OH;+0:12].[:4]-[Fe+;H0:5]-[:6].[:7]-[Fe+;H0:8]-[:9].[OH2;+0:13]
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Title	Authors	Date	PubMed ID
Structure-based design of a highly active vitamin D hydroxylase from Streptomyces griseolus CYP105A1.	Hayashi K, Sugimoto H, Shinkyo R, Yamada M, Ikeda S, Ikushiro S, Kamakura M, Shiro Y, Sakaki T	2008 Nov 18	18937506
Crystal structure of CYP105A1 (P450SU-1) in complex with 1alpha,25-dihydroxyvitamin D3.	Sugimoto H, Shinkyo R, Hayashi K, Yoneda S, Yamada M, Kamakura M, Ikushiro S, Shiro Y, Sakaki T	2008 Apr 1	18314962
Conversion of vitamin D3 to 1alpha,25-dihydroxyvitamin D3 by Streptomyces griseolus cytochrome P450SU-1.	Sawada N, Sakaki T, Yoneda S, Kusudo T, Shinkyo R, Ohta M, Inouye K	2004 Jul 16	15207715

RHEA:50696	calciol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = calcidiol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
RULE(radius=1)	[:1]-[CH;+0:2](-[:3])-[:4].[:5]-[Fe;H0;+0:6]-[:7].[:8]-[Fe;H0;+0:9]-[:10].[H+;H0:11].[H+;H0:12].[O;H0;+0:13]=[O;H0;+0:14]>>[:1]-[C;H0;+0:2](-[:3])(-[:4])-[OH;+0:13].[:5]-[Fe+;H0:6]-[:7].[:8]-[Fe+;H0:9]-[:10].[OH2;+0:14]
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Core-to-Core	More

Title	Authors	Date	PubMed ID
Structure-based design of a highly active vitamin D hydroxylase from Streptomyces griseolus CYP105A1.	Hayashi K, Sugimoto H, Shinkyo R, Yamada M, Ikeda S, Ikushiro S, Kamakura M, Shiro Y, Sakaki T	2008 Nov 18	18937506
Crystal structure of CYP105A1 (P450SU-1) in complex with 1alpha,25-dihydroxyvitamin D3.	Sugimoto H, Shinkyo R, Hayashi K, Yoneda S, Yamada M, Kamakura M, Ikushiro S, Shiro Y, Sakaki T	2008 Apr 1	18314962
Conversion of vitamin D3 to 1alpha,25-dihydroxyvitamin D3 by Streptomyces griseolus cytochrome P450SU-1.	Sawada N, Sakaki T, Yoneda S, Kusudo T, Shinkyo R, Ohta M, Inouye K	2004 Jul 16	15207715