EC number:1.14.15.24
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen |
| 1.14.15 With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor |
| ID: | 1.14.15.24 |
|---|---|
| Description: | Beta-carotene 3-hydroxylase. |
| Alternative Name: |
Beta-carotene 3,3'-monooxygenase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.14.15.24 |
| BRENDA Enzyme Link: | BRENDA 1.14.15.24 |
| KEGG Enzyme Link: | KEGG1.14.15.24 |
| BioCyc Enzyme Link: | BioCyc 1.14.15.24 |
| ExPASy Enzyme Link: | ExPASy1.14.15.24 |
| EC2PDB Enzyme Link: | EC2PDB 1.14.15.24 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.14.15.24 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.14.15.24 |
| IntEnz Enzyme Link: | IntEnz 1.14.15.24 |
| MEDLINE Enzyme Link: | MEDLINE 1.14.15.24 |
EC number:1.14.15.24
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:30331 | all-trans-beta-carotene + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] = all-trans-zeaxanthin + 2 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] |
| RULE(radius=1) | ([*:1]-[CH2;+0:2]-[*:3].[*:4]-[CH2;+0:5]-[*:6]).[*:7]-[Fe;H0;+0:8]-[*:9].[*:10]-[Fe;H0;+0:11]-[*:12].[*:13]-[Fe;H0;+0:14]-[*:15].[*:16]-[Fe;H0;+0:17]-[*:18].[H+;H0:19].[H+;H0:20].[H+;H0:21].[H+;H0:22].[O;H0;+0:23]=[O;H0;+0:24].[O;H0;+0:25]=[O;H0;+0:26]>>([*:1]-[CH;+0:2](-[*:3])-[OH;+0:23].[*:4]-[CH;+0:5](-[*:6])-[OH;+0:24]).[*:7]-[Fe+;H0:8]-[*:9].[*:10]-[Fe+;H0:11]-[*:12].[*:13]-[Fe+;H0:14]-[*:15].[*:16]-[Fe+;H0:17]-[*:18].[OH2;+0:25].[OH2;+0:26] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Xanthophyll biosynthesis: molecular and functional characterization of carotenoid hydroxylases from pepper fruits (Capsicum annuum L.). | Bouvier F, Keller Y, d'Harlingue A, Camara B | 1998 Apr 22 | 9555077 |
| Enzymic confirmation of reactions involved in routes to astaxanthin formation, elucidated using a direct substrate in vitro assay. | Fraser PD, Shimada H, Misawa N | 1998 Mar 1 | 9523693 |
| In vitro characterization of astaxanthin biosynthetic enzymes. | Fraser PD, Miura Y, Misawa N | 1997 Mar 7 | 9045623 |
| Cloning and functional analysis of the beta-carotene hydroxylase of Arabidopsis thaliana. | Sun Z, Gantt E, Cunningham FX Jr | 1996 Oct 4 | 8798688 |
| Characterization of bacterial beta-carotene 3,3'-hydroxylases, CrtZ, and P450 in astaxanthin biosynthetic pathway and adonirubin production by gene combination in Escherichia coli. | Choi SK, Matsuda S, Hoshino T, Peng X, Misawa N | 2006 Oct | 16614859 |
| cDNAs for the synthesis of cyclic carotenoids in petals of Gentiana lutea and their regulation during flower development. | Zhu C, Yamamura S, Nishihara M, Koiwa H, Sandmann G | 2003 Feb 20 | 12591618 |
| Carotenoid hydroxylase from Haematococcus pluvialis: cDNA sequence, regulation and functional complementation. | Linden H | 1999 Sep 3 | 10524195 |