EC number:1.14.15.30
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen |
| 1.14.15 With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor |
| ID: | 1.14.15.30 |
|---|---|
| Description: | 3-ketosteroid 9-alpha-monooxygenase. |
| Alternative Name: |
3-ketosteroid 9-alpha-hydroxylase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.14.15.30 |
| BRENDA Enzyme Link: | BRENDA 1.14.15.30 |
| KEGG Enzyme Link: | KEGG1.14.15.30 |
| BioCyc Enzyme Link: | BioCyc 1.14.15.30 |
| ExPASy Enzyme Link: | ExPASy1.14.15.30 |
| EC2PDB Enzyme Link: | EC2PDB 1.14.15.30 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.14.15.30 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.14.15.30 |
| IntEnz Enzyme Link: | IntEnz 1.14.15.30 |
| MEDLINE Enzyme Link: | MEDLINE 1.14.15.30 |
EC number:1.14.15.30
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:32199 | androsta-1,4-diene-3,17-dione + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 9alpha-hydroxyandrosta-1,4-diene-3,17-dione + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[*:4].[*:5]-[N;H0;+0:6]1-[CH;+0:7]=[C;H0;+0:8](-[*:9])-[CH2;+0:10]-[CH;+0:11]=[CH;+0:12]-1.[H+;H0:13].[O;H0;+0:14]=[O;H0;+0:15]>>[*:1]-[C;H0;+0:2](-[*:3])(-[*:4])-[OH;+0:14].[*:5]-[n+;H0:6]1:[cH;+0:7]:[c;H0;+0:8](-[*:9]):[cH;+0:10]:[cH;+0:11]:[cH;+0:12]:1.[OH2;+0:15] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Activity of 3-ketosteroid 9α-hydroxylase (KshAB) indicates cholesterol side chain and ring degradation occur simultaneously in Mycobacterium tuberculosis. | Capyk JK, Casabon I, Gruninger R, Strynadka NC, Eltis LD | 2011 Nov 25 | 21987574 |
| Rhodococcus rhodochrous DSM 43269 3-ketosteroid 9alpha-hydroxylase, a two-component iron-sulfur-containing monooxygenase with subtle steroid substrate specificity. | Petrusma M, Dijkhuizen L, van der Geize R | 2009 Aug | 19561185 |
| Characterization of 3-ketosteroid 9{alpha}-hydroxylase, a Rieske oxygenase in the cholesterol degradation pathway of Mycobacterium tuberculosis. | Capyk JK, D'Angelo I, Strynadka NC, Eltis LD | 2009 Apr 10 | 19234303 |