EC number:1.14.15.5
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen |
| 1.14.15 With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor |
| ID: | 1.14.15.5 | ||
|---|---|---|---|
| Description: | Corticosterone 18-monooxygenase. | ||
| Alternative Name: |
Corticosterone methyl oxidase. Corticosterone 18-hydroxylase. | ||
| Prosite: | PDOC00081; | ||
| PDB: |
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| Cath: | 1.10.630.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.14.15.5 |
| BRENDA Enzyme Link: | BRENDA 1.14.15.5 |
| KEGG Enzyme Link: | KEGG1.14.15.5 |
| BioCyc Enzyme Link: | BioCyc 1.14.15.5 |
| ExPASy Enzyme Link: | ExPASy1.14.15.5 |
| EC2PDB Enzyme Link: | EC2PDB 1.14.15.5 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.14.15.5 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.14.15.5 |
| IntEnz Enzyme Link: | IntEnz 1.14.15.5 |
| MEDLINE Enzyme Link: | MEDLINE 1.14.15.5 |
EC number:1.14.15.5
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:11872 | corticosterone + 2 H(+) + O2 + 2 reduced [adrenodoxin] = 18-hydroxycorticosterone + H2O + 2 oxidized [adrenodoxin] |
| RULE(radius=1) | [*:1]-[CH3;+0:2].[*:3]-[Fe;H0;+0:4]-[*:5].[*:6]-[Fe;H0;+0:7]-[*:8].[H+;H0:9].[H+;H0:10].[O;H0;+0:11]=[O;H0;+0:12]>>[*:1]-[CH2;+0:2]-[OH;+0:11].[*:3]-[Fe+;H0:4]-[*:5].[*:6]-[Fe+;H0:7]-[*:8].[OH2;+0:12] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Isolated aldosterone synthase deficiency caused by simultaneous E198D and V386A mutations in the CYP11B2 gene. | Portrat-Doyen S, Tourniaire J, Richard O, Mulatero P, Aupetit-Faisant B, Curnow KM, Pascoe L, Morel Y | 1998 Nov | 9814506 |
| Studies on aldosterone biosynthesis in vitro. | Raman PB, Sharma DC, Dorfman RI | 1966 Jun | 4381410 |
| Mutations in the human CYP11B2 (aldosterone synthase) gene causing corticosterone methyloxidase II deficiency. | Pascoe L, Curnow KM, Slutsker L, Rösler A, White PC | 1992 Jun 1 | 1594605 |
| The effect of amino-acid substitutions I112P, D147E and K152N in CYP11B2 on the catalytic activities of the enzyme. | Bechtel S, Belkina N, Bernhardt R | 2002 Feb | 11856349 |