EC number:1.14.16.7

Enzyme

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     1. Oxidoreductases
        1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
            1.14.16 With reduced pteridine as one donor, and incorporation of one atom of oxygen into the other donor
ID:1.14.16.7
Description:Phenylalanine 3-monooxygenase.
Alternative Name: Phenylalanine 3-hydroxylase.

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 1.14.16.7
BRENDA Enzyme Link: BRENDA 1.14.16.7
KEGG Enzyme Link: KEGG1.14.16.7
BioCyc Enzyme Link: BioCyc 1.14.16.7
ExPASy Enzyme Link: ExPASy1.14.16.7
EC2PDB Enzyme Link: EC2PDB 1.14.16.7
ExplorEnz Enzyme Link: ExplorEnz 1.14.16.7
PRIAM enzyme-specific profiles Link: PRIAM 1.14.16.7
IntEnz Enzyme Link: IntEnz 1.14.16.7
MEDLINE Enzyme Link: MEDLINE 1.14.16.7

EC number:1.14.16.7

MSA:

1.14.16.7;
Phylogenetic Tree:

1.14.16.7;
Uniprot:
M-CSA:
RHEA:41532 (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + 3-hydroxy-L-phenylalanine
RULE(radius=1) [*:1]-[c;H0;+0:2]1:[c;H0;+0:3](=[*:4]):[nH;+0:5]:[c;H0;+0:6](-[*:7]):[n;H0;+0:8]:[c;H0;+0:9]:1-[*:10].[*:11]:[cH;+0:12]:[*:13].[O;H0;+0:14]=[O;H0;+0:15]>>[*:1]-[C;H0;+0:2]1(-[OH;+0:14])-[C;H0;+0:3](=[*:4])-[N;H0;+0:5]=[C;H0;+0:6](-[*:7])-[N;H0;+0:8]=[C;H0;+0:9]-1-[*:10].[*:11]:[c;H0;+0:12](:[*:13])-[OH;+0:15]
Reaction
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References

TitleAuthorsDatePubMed ID
Identification of phenylalanine 3-hydroxylase for meta-tyrosine biosynthesis.Zhang W, Ames BD, Walsh CT2011 Jun 2121615132