EC number:1.14.19.21
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen |
| 1.14.19 With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water |
| ID: | 1.14.19.21 |
|---|---|
| Description: | Cholesterol 7-desaturase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.14.19.21 |
| BRENDA Enzyme Link: | BRENDA 1.14.19.21 |
| KEGG Enzyme Link: | KEGG1.14.19.21 |
| BioCyc Enzyme Link: | BioCyc 1.14.19.21 |
| ExPASy Enzyme Link: | ExPASy1.14.19.21 |
| EC2PDB Enzyme Link: | EC2PDB 1.14.19.21 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.14.19.21 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.14.19.21 |
| IntEnz Enzyme Link: | IntEnz 1.14.19.21 |
| MEDLINE Enzyme Link: | MEDLINE 1.14.19.21 |
EC number:1.14.19.21
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:51644 | cholesterol + H(+) + NADH + O2 = cholesta-5,7-dien-3beta-ol + 2 H2O + NAD(+) |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[CH;+0:3](-[*:4])-[*:5].[*:6]-[N;H0;+0:7]1-[CH;+0:8]=[C;H0;+0:9](-[*:10])-[CH2;+0:11]-[CH;+0:12]=[CH;+0:13]-1.[H+;H0:14].[O;H0;+0:15]=[O;H0;+0:16]>>[*:1]-[CH;+0:2]=[C;H0;+0:3](-[*:4])-[*:5].[*:6]-[n+;H0:7]1:[cH;+0:8]:[c;H0;+0:9](-[*:10]):[cH;+0:11]:[cH;+0:12]:[cH;+0:13]:1.[OH2;+0:15].[OH2;+0:16] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Mechanism and Catalytic Diversity of Rieske Non-Heme Iron-Dependent Oxygenases. | Barry SM, Challis GL | 2013 Oct 4 | 24244885 |
| The Sterol-C7 desaturase from the ciliate Tetrahymena thermophila is a Rieske Oxygenase, which is highly conserved in animals. | Najle SR, Nusblat AD, Nudel CB, Uttaro AD | 2013 Jul | 23603937 |
| The Rieske oxygenase DAF-36 functions as a cholesterol 7-desaturase in steroidogenic pathways governing longevity. | Wollam J, Magomedova L, Magner DB, Shen Y, Rottiers V, Motola DL, Mangelsdorf DJ, Cummins CL, Antebi A | 2011 Oct | 21749634 |
| The conserved Rieske oxygenase DAF-36/Neverland is a novel cholesterol-metabolizing enzyme. | Yoshiyama-Yanagawa T, Enya S, Shimada-Niwa Y, Yaguchi S, Haramoto Y, Matsuya T, Shiomi K, Sasakura Y, Takahashi S, Asashima M, Kataoka H, Niwa R | 2011 Jul 22 | 21632547 |
| RHEA:45024 | cholesterol + H(+) + NADPH + O2 = cholesta-5,7-dien-3beta-ol + 2 H2O + NADP(+) |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[CH;+0:3](-[*:4])-[*:5].[*:6]-[N;H0;+0:7]1-[CH;+0:8]=[C;H0;+0:9](-[*:10])-[CH2;+0:11]-[CH;+0:12]=[CH;+0:13]-1.[H+;H0:14].[O;H0;+0:15]=[O;H0;+0:16]>>[*:1]-[CH;+0:2]=[C;H0;+0:3](-[*:4])-[*:5].[*:6]-[n+;H0:7]1:[cH;+0:8]:[c;H0;+0:9](-[*:10]):[cH;+0:11]:[cH;+0:12]:[cH;+0:13]:1.[OH2;+0:15].[OH2;+0:16] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Mechanism and Catalytic Diversity of Rieske Non-Heme Iron-Dependent Oxygenases. | Barry SM, Challis GL | 2013 Oct 4 | 24244885 |
| The Sterol-C7 desaturase from the ciliate Tetrahymena thermophila is a Rieske Oxygenase, which is highly conserved in animals. | Najle SR, Nusblat AD, Nudel CB, Uttaro AD | 2013 Jul | 23603937 |
| The Rieske oxygenase DAF-36 functions as a cholesterol 7-desaturase in steroidogenic pathways governing longevity. | Wollam J, Magomedova L, Magner DB, Shen Y, Rottiers V, Motola DL, Mangelsdorf DJ, Cummins CL, Antebi A | 2011 Oct | 21749634 |
| The conserved Rieske oxygenase DAF-36/Neverland is a novel cholesterol-metabolizing enzyme. | Yoshiyama-Yanagawa T, Enya S, Shimada-Niwa Y, Yaguchi S, Haramoto Y, Matsuya T, Shiomi K, Sasakura Y, Takahashi S, Asashima M, Kataoka H, Niwa R | 2011 Jul 22 | 21632547 |