EC number:1.14.19.41
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen |
| 1.14.19 With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water |
| ID: | 1.14.19.41 |
|---|---|
| Description: | Sterol 22-desaturase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.14.19.41 |
| BRENDA Enzyme Link: | BRENDA 1.14.19.41 |
| KEGG Enzyme Link: | KEGG1.14.19.41 |
| BioCyc Enzyme Link: | BioCyc 1.14.19.41 |
| ExPASy Enzyme Link: | ExPASy1.14.19.41 |
| EC2PDB Enzyme Link: | EC2PDB 1.14.19.41 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.14.19.41 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.14.19.41 |
| IntEnz Enzyme Link: | IntEnz 1.14.19.41 |
| MEDLINE Enzyme Link: | MEDLINE 1.14.19.41 |
EC number:1.14.19.41
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:46576 | (24R)-ethylcholest-5-en-3beta-ol + H(+) + NADPH + O2 = 2 H2O + NADP(+) + stigmasterol |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[CH2;+0:3]-[*:4].[*:5]-[N;H0;+0:6]1-[CH;+0:7]=[C;H0;+0:8](-[*:9])-[CH2;+0:10]-[CH;+0:11]=[CH;+0:12]-1.[H+;H0:13].[O;H0;+0:14]=[O;H0;+0:15]>>[*:1]-[CH;+0:2]=[CH;+0:3]-[*:4].[*:5]-[n+;H0:6]1:[cH;+0:7]:[c;H0;+0:8](-[*:9]):[cH;+0:10]:[cH;+0:11]:[cH;+0:12]:1.[OH2;+0:14].[OH2;+0:15] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Cytochrome P450 CYP710A encodes the sterol C-22 desaturase in Arabidopsis and tomato. | Morikawa T, Mizutani M, Aoki N, Watanabe B, Saga H, Saito S, Oikawa A, Suzuki H, Sakurai N, Shibata D, Wadano A, Sakata K, Ohta D | 2006 Apr | 16531502 |
| RHEA:33467 | ergosta-5,7,24(28)-trien-3beta-ol + H(+) + NADPH + O2 = ergosta-5,7,22,24(28)-tetraen-3beta-ol + 2 H2O + NADP(+) |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[CH2;+0:3]-[*:4].[*:5]-[N;H0;+0:6]1-[CH;+0:7]=[C;H0;+0:8](-[*:9])-[CH2;+0:10]-[CH;+0:11]=[CH;+0:12]-1.[H+;H0:13].[O;H0;+0:14]=[O;H0;+0:15]>>[*:1]-[CH;+0:2]=[CH;+0:3]-[*:4].[*:5]-[n+;H0:6]1:[cH;+0:7]:[c;H0;+0:8](-[*:9]):[cH;+0:10]:[cH;+0:11]:[cH;+0:12]:1.[OH2;+0:14].[OH2;+0:15] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Cloning and characterization of the Saccharomyces cerevisiae C-22 sterol desaturase gene, encoding a second cytochrome P-450 involved in ergosterol biosynthesis. | Skaggs BA, Alexander JF, Pierson CA, Schweitzer KS, Chun KT, Koegel C, Barbuch R, Bard M | 1996 Feb 22 | 8635732 |
| Purification and reconstitution of activity of Saccharomyces cerevisiae P450 61, a sterol delta 22-desaturase. | Kelly SL, Lamb DC, Corran AJ, Baldwin BC, Parks LW, Kelly DE | 1995 Dec 18 | 8543054 |
| Interactions of the ergosterol biosynthetic pathway with other lipid pathways. | Veen M, Lang C | 2005 Nov | 16246076 |