EC number:1.14.19.49

Enzyme

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     1. Oxidoreductases
        1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
            1.14.19 With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water
ID:1.14.19.49
Description:Tetracycline 7-halogenase.

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 1.14.19.49
BRENDA Enzyme Link: BRENDA 1.14.19.49
KEGG Enzyme Link: KEGG1.14.19.49
BioCyc Enzyme Link: BioCyc 1.14.19.49
ExPASy Enzyme Link: ExPASy1.14.19.49
EC2PDB Enzyme Link: EC2PDB 1.14.19.49
ExplorEnz Enzyme Link: ExplorEnz 1.14.19.49
PRIAM enzyme-specific profiles Link: PRIAM 1.14.19.49
IntEnz Enzyme Link: IntEnz 1.14.19.49
MEDLINE Enzyme Link: MEDLINE 1.14.19.49

EC number:1.14.19.49

MSA:

1.14.19.49;
Phylogenetic Tree:

1.14.19.49;
Uniprot:
M-CSA:
RHEA:50712 chloride + FADH2 + O2 + tetracycline = 7-chlorotetracycline + FAD + H(+) + 2 H2O
RULE(radius=1) [*:1]-[N;H0;+0:2]1-[*:3]:[*:4]-[NH;+0:5]-[c;H0;+0:6](:[*:7]):[c;H0;+0:8]-1:[nH;+0:9]:[*:10].[*:11]:[cH;+0:12]:[*:13].[Cl-;H0:14].[O;H0;+0:15]=[O;H0;+0:16]>>[*:1]-[n;H0;+0:2]1:[*:3]:[*:4]:[n;H0;+0:5]:[c;H0;+0:6](:[*:7])-[c;H0;+0:8]:1:[n;H0;+0:9]:[*:10].[*:11]:[c;H0;+0:12](:[*:13])-[Cl;H0;+0:14].[OH2;+0:15].[OH2;+0:16]
Reaction
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References

TitleAuthorsDatePubMed ID
Cloning and nucleotide sequence of the gene responsible for chlorination of tetracycline.Dairi T, Nakano T, Aisaka K, Katsumata R, Hasegawa M1995 Jun7612997
Deciphering and engineering of the final step halogenase for improved chlortetracycline biosynthesis in industrial Streptomyces aureofaciens.Zhu T, Cheng X, Liu Y, Deng Z, You D2013 Sep23800859